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Bintrafusp alfa
🥰Excellent
Catalog No. T80588Cas No. 1918149-01-5
Alias MSB-0011359C, MSB0011359C, M-7824, M7824, GSK-4045154, GSK4045154
Bintrafusp alfa (M7824) is a bifunctional fusion protein consisting of the extracellular structural domain of TGF-βRII (a TGF-β "trap") fused to a monoclonal antibody against human immunoglobulin G1 fused to programmed death ligand 1 (PD-L1), which is known for its anticancer activity, and can be used to study esophageal cancer. It has anticancer activity and can be used to study esophageal cancer.
Bintrafusp alfa
Bintrafusp alfa
🥰Excellent
Catalog No. T80588Alias MSB-0011359C, MSB0011359C, M-7824, M7824, GSK-4045154, GSK4045154Cas No. 1918149-01-5
Bintrafusp alfa (M7824) is a bifunctional fusion protein consisting of the extracellular structural domain of TGF-βRII (a TGF-β "trap") fused to a monoclonal antibody against human immunoglobulin G1 fused to programmed death ligand 1 (PD-L1), which is known for its anticancer activity, and can be used to study esophageal cancer. It has anticancer activity and can be used to study esophageal cancer.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $263 | - | In Stock | |
| 5 mg | $689 | - | In Stock | |
| 10 mg | $1,080 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:96.1% (SDS-PAGE); 99.2% (SEC-HPLC)
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Product Introduction
Bioactivity
Chemical Properties
| Description | Bintrafusp alfa (M7824) is a bifunctional fusion protein consisting of the extracellular structural domain of TGF-βRII (a TGF-β "trap") fused to a monoclonal antibody against human immunoglobulin G1 fused to programmed death ligand 1 (PD-L1), which is known for its anticancer activity, and can be used to study esophageal cancer. It has anticancer activity and can be used to study esophageal cancer. |
| In vitro | Bintrafusp alfa is capable of providing sustained protective immunity, reducing the function of regulatory T cells, significantly increasing the infiltration of CD8+ T cells and natural killer cells, while also decreasing the infiltration of bone marrow-derived suppressor cells within the tumor. [1] |
| Synonyms | MSB-0011359C, MSB0011359C, M-7824, M7824, GSK-4045154, GSK4045154 |
| Cas No. | 1918149-01-5 |
Storage & Solubility Information
| Storage | store at low temperature | -20°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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