Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Bintrafusp alfa (M 7824), a pioneering bifunctional fusion protein, integrates the extracellular domain of TGF-βRII with a human IgG1 monoclonal antibody that inhibits the programmed cell death ligand. This compound is utilized in cancer research [1].
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Description | Bintrafusp alfa (M 7824), a pioneering bifunctional fusion protein, integrates the extracellular domain of TGF-βRII with a human IgG1 monoclonal antibody that inhibits the programmed cell death ligand. This compound is utilized in cancer research [1]. |
In vitro | Bintrafusp alfa confers sustained protective immunity, diminishes regulatory T cell function, significantly enhances CD8+ T cell and natural killer (NK) cell infiltration, and reduces tumor-infiltrating myeloid-derived suppressor cell (MDSC) infiltration [1]. |
Synonyms | M7824, MSB0011359C |
Molecular Weight | N/A |
CAS No. | 1918149-01-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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Bintrafusp alfa 1918149-01-5 M7824 MSB0011359C inhibitor inhibit