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Bintrafusp alfa
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Catalog No. T80588Cas No. 1918149-01-5
Alias MSB-0011359C, MSB0011359C, M-7824, M7824, GSK-4045154, GSK4045154
Bintrafusp alfa (M7824) is a bifunctional fusion protein consisting of the extracellular structural domain of TGF-βRII (a TGF-β "trap") fused to a monoclonal antibody against human immunoglobulin G1 fused to programmed death ligand 1 (PD-L1), which is known for its anticancer activity, and can be used to study esophageal cancer. It has anticancer activity and can be used to study esophageal cancer.
Bintrafusp alfa
Bintrafusp alfa
😃Good
Catalog No. T80588Alias MSB-0011359C, MSB0011359C, M-7824, M7824, GSK-4045154, GSK4045154Cas No. 1918149-01-5
Bintrafusp alfa (M7824) is a bifunctional fusion protein consisting of the extracellular structural domain of TGF-βRII (a TGF-β "trap") fused to a monoclonal antibody against human immunoglobulin G1 fused to programmed death ligand 1 (PD-L1), which is known for its anticancer activity, and can be used to study esophageal cancer. It has anticancer activity and can be used to study esophageal cancer.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $263 | - | In Stock | |
| 5 mg | $689 | - | In Stock | |
| 10 mg | $1,080 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:96.1% (SDS-PAGE); 99.2% (SEC-HPLC)
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| Description | Bintrafusp alfa (M7824) is a bifunctional fusion protein consisting of the extracellular structural domain of TGF-βRII (a TGF-β "trap") fused to a monoclonal antibody against human immunoglobulin G1 fused to programmed death ligand 1 (PD-L1), which is known for its anticancer activity, and can be used to study esophageal cancer. It has anticancer activity and can be used to study esophageal cancer. |
| In vitro | Bintrafusp alfa is capable of providing sustained protective immunity, reducing the function of regulatory T cells, significantly increasing the infiltration of CD8+ T cells and natural killer cells, while also decreasing the infiltration of bone marrow-derived suppressor cells within the tumor. [1] |
| Synonyms | MSB-0011359C, MSB0011359C, M-7824, M7824, GSK-4045154, GSK4045154 |
| Reactivity | Human |
| Application | Functional assay |
| Antibody Type | Monoclonal |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Gene ID | |
| Uniprot ID | |
| Target | B7-H1/PD-L1/CD274 & TGFβ |
| Molecular Weight | 177.25 kDa |
| Cas No. | 1918149-01-5 |
| Isotype | Human IgG1 lambda1 |
| Recommended Isotype Control |
| Storage | store at low temperature | -20°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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