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Bintrafusp alfa (Synonyms: MSB-0011359C, MSB0011359C, M-7824, M7824, GSK-4045154, GSK4045154)
Catalog No. T80588 Copy Product Info
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Bintrafusp alfa (M7824) is a bifunctional fusion protein consisting of the extracellular structural domain of TGF-βRII (a TGF-β "trap") fused to a monoclonal antibody against human immunoglobulin G1 fused to programmed death ligand 1 (PD-L1), which is known for its anticancer activity, and can be used to study esophageal cancer. It has anticancer activity and can be used to study esophageal cancer.
Bintrafusp alfa
Copy Product Info🥰Excellent
Catalog No. T80588
Synonyms MSB-0011359C, MSB0011359C, M-7824, M7824, GSK-4045154, GSK4045154
Bintrafusp alfa (M7824) is a bifunctional fusion protein consisting of the extracellular structural domain of TGF-βRII (a TGF-β "trap") fused to a monoclonal antibody against human immunoglobulin G1 fused to programmed death ligand 1 (PD-L1), which is known for its anticancer activity, and can be used to study esophageal cancer. It has anticancer activity and can be used to study esophageal cancer.
Bintrafusp alfa
Cas No. 1918149-01-5
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 1 mg | $263 | - | In Stock | |
| 5 mg | $689 | - | In Stock | |
| 10 mg | $1,080 | - | In Stock |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:96.1% (SDS-PAGE); 99.2% (SEC-HPLC)
Appearance:Liquid
Color:Transparent
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Product Introduction
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Related Conjugates and Formulations
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Chemical Properties
Antibody Information
Storage & Solubility Information
| Description | Bintrafusp alfa (M7824) is a bifunctional fusion protein consisting of the extracellular structural domain of TGF-βRII (a TGF-β "trap") fused to a monoclonal antibody against human immunoglobulin G1 fused to programmed death ligand 1 (PD-L1), which is known for its anticancer activity, and can be used to study esophageal cancer. It has anticancer activity and can be used to study esophageal cancer. |
| In vitro | Bintrafusp alfa is capable of providing sustained protective immunity, reducing the function of regulatory T cells, significantly increasing the infiltration of CD8+ T cells and natural killer cells, while also decreasing the infiltration of bone marrow-derived suppressor cells within the tumor. [1] |
| Synonyms | MSB-0011359C, MSB0011359C, M-7824, M7824, GSK-4045154, GSK4045154 |
| Reactivity | Human |
| Application | Functional assay |
| Antibody Type | Monoclonal |
| Formulation | Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition. |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Gene ID | |
| Uniprot ID | |
| Target | B7-H1/PD-L1/CD274 & TGFβ |
| Molecular Weight | 177.25 kDa |
| Cas No. | 1918149-01-5 |
| Isotype | Human IgG1 lambda1 |
| Recommended Isotype Control |
| Storage | Store at low temperature | Shipping with blue ice/Shipping at ambient temperature. |
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