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FGFR1/DDR2 inhibitor 1

Name: FGFR1/DDR2 inhibitor 1
Brand: TargetMol
SKU: T11279
Price: 93 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T11279Cas No. 2308497-58-5

FGFR1/DDR2 inhibitor 1 is an inhibitor of discoidin domain receptor 2 (DDR2) and fibroblast growth factor receptor 1 (FGFR1), with IC50 values of 31.1 nM, 108.4 nM, and 3.2 nM for FGFR1, KG-1, and DDR2, respectively.

FGFR1/DDR2 inhibitor 1

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Purity: 99.43%

Catalog No. T11279Cas No. 2308497-58-5

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$93	In Stock	In Stock
5 mg	$228	In Stock	In Stock
10 mg	$372	In Stock	In Stock
25 mg	$612	In Stock	In Stock
50 mg	$845	In Stock	In Stock
100 mg	$1,230	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$253	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.43%

Appearance:Solid

Color:White

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COA HNMR HPLC LCMS

Product Introduction

FGFR1/DDR2 inhibitor 1 AI Summary

FGFR1/DDR2 inhibitor 1 exhibits a wide range of bioactivities, including antiproliferative effects against various cell lines such as human KG1, NCI-H2286, FGFR1-fused human KG1, FGFR2-amplified human SNU16, NCI-H716, UM-UC-14 with FGFR3 mutation, and NCI-H2286 with DDR2 mutation, with differing IC50 values. It also inhibits several kinases like FGFR1, DDR2, ABL, ALK, AXL, BTK, c-Met, c-Src, CSF-1R, and CDK1. The compound demonstrates antitumor activity in NCI-H1581 cells xenografted in nude mice at different doses and exhibits reversible and time-dependent irreversible inhibition of several CYP enzymes in human liver microsomes. Moreover, it inhibits human ERG and shows specific pharmacokinetic parameters in mice, such as Tmax, Cmax, AUC, and MRT..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	FGFR1/DDR2 inhibitor 1 is an inhibitor of discoidin domain receptor 2 (DDR2) and fibroblast growth factor receptor 1 (FGFR1), with IC50 values of 31.1 nM, 108.4 nM, and 3.2 nM for FGFR1, KG-1, and DDR2, respectively.
Targets&IC50	KG-1:108.4 nM , DDR2:3.2 nM, FGFR1:31.1 nM

Chemical Properties

Molecular Weight	501.5
Formula	C₂₈H₂₂F₃N₅O
Cas No.	2308497-58-5
Smiles	Cc1ccc(cc1-c1ccc2c(n[nH]c2c1)-c1cnn(c1)C1CC1)C(=O)Nc1cccc(c1)C(F)(F)F
Relative Density.	1.42 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 250 mg/mL (498.5 mM), Sonication is recommended.

H2O: < 0.1 mg/mL (insoluble)

In Vivo Formulation

10% DMSO+90% Corn Oil: 3.3 mg/mL (6.58 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9940 mL	9.9701 mL	19.9402 mL	99.7009 mL
5 mM	0.3988 mL	1.9940 mL	3.9880 mL	19.9402 mL
10 mM	0.1994 mL	0.9970 mL	1.9940 mL	9.9701 mL
20 mM	0.0997 mL	0.4985 mL	0.9970 mL	4.9850 mL
50 mM	0.0399 mL	0.1994 mL	0.3988 mL	1.9940 mL
100 mM	0.0199 mL	0.0997 mL	0.1994 mL	0.9970 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc