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FGFR1/DDR2 inhibitor 1

Name: FGFR1/DDR2 inhibitor 1
Brand: TargetMol
SKU: T11279
Price: 93 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T11279Cas No. 2308497-58-5

FGFR1/DDR2 inhibitor 1 is an inhibitor of discoidin domain receptor 2 (DDR2) and fibroblast growth factor receptor 1 (FGFR1), with IC50 values of 31.1 nM, 108.4 nM, and 3.2 nM for FGFR1, KG-1, and DDR2, respectively.

FGFR1/DDR2 inhibitor 1

🥰Excellent

Purity: 99.43%

Catalog No. T11279Cas No. 2308497-58-5

Pack Size	Price	Availability
1 mg	$93	In Stock
5 mg	$228	In Stock
10 mg	$372	In Stock
25 mg	$612	In Stock
50 mg	$845	In Stock
100 mg	$1,230	In Stock
1 mL x 10 mM (in DMSO)	$253	In Stock

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Batch Information

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Purity:99.43%

Resource Download

COA HNMR HPLC LCMS

Product Introduction

Bioactivity

Description	FGFR1/DDR2 inhibitor 1 is an inhibitor of discoidin domain receptor 2 (DDR2) and fibroblast growth factor receptor 1 (FGFR1), with IC50 values of 31.1 nM, 108.4 nM, and 3.2 nM for FGFR1, KG-1, and DDR2, respectively.
Targets&IC50	DDR2:3.2 nM, KG-1:108.4 nM , FGFR1:31.1 nM

Chemical Properties

Molecular Weight	501.5
Formula	C₂₈H₂₂F₃N₅O
Cas No.	2308497-58-5
Smiles	Cc1ccc(cc1-c1ccc2c(n[nH]c2c1)-c1cnn(c1)C1CC1)C(=O)Nc1cccc(c1)C(F)(F)F
Relative Density.	1.42 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 250 mg/mL (498.50 mM), Sonication is recommended.

H2O: < 0.1 mg/mL (insoluble)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9940 mL	9.9701 mL	19.9402 mL	99.7009 mL
5 mM	0.3988 mL	1.9940 mL	3.9880 mL	19.9402 mL
10 mM	0.1994 mL	0.9970 mL	1.9940 mL	9.9701 mL
20 mM	0.0997 mL	0.4985 mL	0.9970 mL	4.9850 mL
50 mM	0.0399 mL	0.1994 mL	0.3988 mL	1.9940 mL
100 mM	0.0199 mL	0.0997 mL	0.1994 mL	0.9970 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc