Ecopipam hydrobromide

Name: Ecopipam hydrobromide
Brand: TargetMol
SKU: T73709
Rating: 4.5 (1 reviews)

Copy Product Info

🥰Excellent

Catalog No. T73709Cas No. 2587360-22-1

Ecopipam (SCH 39166) hydrobromide is a highly potent, specific, and orally active dopamine D1/D5 receptor antagonist with K i values of 1.2 nM for D1 and 2.0 nM for D5 receptors. It shows over 40-fold greater selectivity for D1/D5 over D2, D4, 5-HT, and α2a receptors, with K i values of 0.98, 5.52, 0.08, and 0.73 μM, respectively, and is relevant for schizophrenia and obesity research.

Ecopipam hydrobromide

Copy Product Info

🥰Excellent

Catalog No. T73709Cas No. 2587360-22-1

Product information is being updated, if you want to purchase, please click the bulk custom button.

Add to Quotation

Questions

Resource Download

Product Introduction

Bioactivity

Description	Ecopipam (SCH 39166) hydrobromide is a highly potent, specific, and orally active dopamine D1/D5 receptor antagonist with K i values of 1.2 nM for D1 and 2.0 nM for D5 receptors. It shows over 40-fold greater selectivity for D1/D5 over D2, D4, 5-HT, and α2a receptors, with K i values of 0.98, 5.52, 0.08, and 0.73 μM, respectively, and is relevant for schizophrenia and obesity research.
Targets&IC50	D4 Receptor:5520 nM (Ki), D5 receptor:2.0 nM (Ki), D2 Receptor:980 nM (Ki), D1 receptor:1.2 nM (Ki), α2A-adrenoceptor:731 nM (Ki), 5-HT receptor:80 nM (Ki)

Chemical Properties

Molecular Weight	394.73
Formula	C₁₉H₂₁BrClNO
Cas No.	2587360-22-1
Smiles	Br.CN1CCc2cc(Cl)c(O)cc2[C@@H]2[C@@H]1CCc1ccccc21

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc