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BAFF/TNFSF13B Protein, Human, Recombinant (Avi & hFc), Biotinylated

Catalog No. TMPJ-00177
Synonyms: BAFF, Dendritic cell-derived TNF-like molecule, CD257, B lymphocyte stimulator, Tumor necrosis factor ligand superfamily member 13B, TNFSF13B, ZTNF4, B-cell-activating factor, TNFSF20, BLyS, TNF- and APOL-related leukocyte expressed ligand 1, TALL-1

B-cell activating factor (BAFF), also known as BLyS, TALL-1, THANK, and TNFSF13B, is a transmembrane glycoprotein in the TNF ligand superfamily. BAFF is a cytokine and serves as a ligand for receptors TNFRSF13B (TACI), TNFRSF17 (BCMA), and TNFRSF13C (BAFFR). BAFF can promotes the survival, proliferation and maturation of B lymphocytes, which are key elements in the pathogenesis of systemic lupus erythematosus (SLE). This cytokine is encoded on TNFSF13B gene, and diverse single-nucleotide polymorphisms have been associated with susceptibility in diferent autoimmune disorders. BAFF is a transmembranal protein expressed on myeloid lineage and some epithelial cells, through diferent stimuli such as IFN-γ, IFN-α, interleukin (IL)-10, Toll-like receptors (TLR)-3, TLR-4 and TLR-7.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
BAFF/TNFSF13B Protein, Human, Recombinant (Avi & hFc), Biotinylated
Pack Size Availability Price/USD Quantity
20 μg 5 days $ 355.00
100 μg 5 days $ 963.00
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Biological Description
Technical Params
Product Properties
Description B-cell activating factor (BAFF), also known as BLyS, TALL-1, THANK, and TNFSF13B, is a transmembrane glycoprotein in the TNF ligand superfamily. BAFF is a cytokine and serves as a ligand for receptors TNFRSF13B (TACI), TNFRSF17 (BCMA), and TNFRSF13C (BAFFR). BAFF can promotes the survival, proliferation and maturation of B lymphocytes, which are key elements in the pathogenesis of systemic lupus erythematosus (SLE). This cytokine is encoded on TNFSF13B gene, and diverse single-nucleotide polymorphisms have been associated with susceptibility in diferent autoimmune disorders. BAFF is a transmembranal protein expressed on myeloid lineage and some epithelial cells, through diferent stimuli such as IFN-γ, IFN-α, interleukin (IL)-10, Toll-like receptors (TLR)-3, TLR-4 and TLR-7.
Species Human
Expression System Human Cells
Tag N-Avi-Fc
Accession Number Q9Y275
Synonyms BAFF, Dendritic cell-derived TNF-like molecule, CD257, B lymphocyte stimulator, Tumor necrosis factor ligand superfamily member 13B, TNFSF13B, ZTNF4, B-cell-activating factor, TNFSF20, BLyS, TNF- and APOL-related leukocyte expressed ligand 1, TALL-1
Amino Acid Ala134-Leu285
Construction Biotinylated Recombinant Human B-cell-activating factor is produced by our Mammalian expression system and the target gene encoding Ala134-Leu285 is expressed with a Avi tag and a Fc tag at the N-terminus.
Protein Purity Greater than 95% as determined by reducing SDS-PAGE. (QC verified)
Molecular Weight 50-60 KDa, reducing conditions
Endotoxin Less than 0.1 ng/µg (1 EU/µg) as determined by LAL test.
Formulation Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
Reconstitution Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. 
Stability & Storage

Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.
Shipping

The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature listed below.
Research Background B-cell activating factor (BAFF), also known as BLyS, TALL-1, THANK, and TNFSF13B, is a transmembrane glycoprotein in the TNF ligand superfamily. BAFF is a cytokine and serves as a ligand for receptors TNFRSF13B (TACI), TNFRSF17 (BCMA), and TNFRSF13C (BAFFR). BAFF can promotes the survival, proliferation and maturation of B lymphocytes, which are key elements in the pathogenesis of systemic lupus erythematosus (SLE). This cytokine is encoded on TNFSF13B gene, and diverse single-nucleotide polymorphisms have been associated with susceptibility in diferent autoimmune disorders. BAFF is a transmembranal protein expressed on myeloid lineage and some epithelial cells, through diferent stimuli such as IFN-γ, IFN-α, interleukin (IL)-10, Toll-like receptors (TLR)-3, TLR-4 and TLR-7.

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Keywords

BAFF/TNFSF13B Protein, Human, Recombinant (Avi & hFc), Biotinylated CD 257 BAFF Dendritic cell-derived TNF-like molecule CD257 B lymphocyte stimulator TNFSF-20 Tumor necrosis factor ligand superfamily member 13B TNFSF 20 TNFSF13B ZTNF 4 CD-257 TALL 1 ZTNF4 B-cell-activating factor ZTNF-4 TALL1 TNFSF20 BLyS TNF- and APOL-related leukocyte expressed ligand 1 TALL-1 recombinant recombinant-proteins proteins protein

 

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