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Anti-Phospho-KSR1 (Ser404) Polyclonal Antibody

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Catalog No. TMAB-10899

Anti-Phospho-KSR1 (Ser404) Polyclonal Antibody is a Rabbit antibody targeting Phospho-KSR1 (Ser404). Anti-Phospho-KSR1 (Ser404) Polyclonal Antibody can be used in WB.

Anti-Phospho-KSR1 (Ser404) Polyclonal Antibody

Anti-Phospho-KSR1 (Ser404) Polyclonal Antibody

😃Good
Catalog No. TMAB-10899
Anti-Phospho-KSR1 (Ser404) Polyclonal Antibody is a Rabbit antibody targeting Phospho-KSR1 (Ser404). Anti-Phospho-KSR1 (Ser404) Polyclonal Antibody can be used in WB.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
50 μL$2237-10 days7-10 days
100 μL$3727-10 days7-10 days
200 μL$5277-10 days7-10 days
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
Anti-Phospho-KSR1 (Ser404) Polyclonal Antibody is a Rabbit antibody targeting Phospho-KSR1 (Ser404). Anti-Phospho-KSR1 (Ser404) Polyclonal Antibody can be used in WB.
Ig Type
IgG
Reactivity
Human (predicted:Mouse,Rat,Dog,Pig)
Application
WB
Recommended Dose
WB: 1:500-2000
Antibody Type
Polyclonal
Host SpeciesRabbit
Subcellular LocalizationCytoplasm. Membrane. In unstimulated cells, where the phosphorylated form is bound to a 14-3-3 protein, sequestration in the cytoplasm occurs. Following growth factor treatment, the protein is free for membrane translocation, and it moves from the cytoplasm to the cell periphery.
ConstructionPolyclonal Antibody
PurificationProtein A purified
AppearanceLiquid
Formulation0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Concentration1mg/ml
Research BackgroundKSR1 is a molecular scaffold and positive regulator of the Raf/MEK/ERK phosphorylation cascade. It was initially considered to be a protein kinase acting in the Ras pathway. KSR1 is required for maximal ERK activation induced by growth factors and by some cytotoxic agents. In resting cells, phosphorylated KSR1 is cytoplasmic and in stimulated cells, dephosphorylated KSR1 is membrane associated.
Antigen Details
Immunogen
KLH conjugated synthesised phosphopeptide: human KSR1 around the phosphorylation site of Ser404
Antigen Species
Human
Gene Name
KSR1
Gene ID
8844
Protein Name
Kinase suppressor of Ras 1
Uniprot ID
Q8IVT5
Function
Location-regulated scaffolding protein connecting MEK to RAF. Promotes MEK and RAF phosphorylation and activity through assembly of an activated signaling complex. By itself, it has no demonstrated kinase activity.
Chemical Properties
Molecular WeightTheoretical: 102 kDa.
Stability & Storage
Stability & StorageStore at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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