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(4-NH2)-Exatecan

🥰Excellent
Catalog No. T40159Cas No. 2495742-21-5

(4-NH2)-Exatecan is a topoisomerase inhibitor with potential anticancer activity for the synthesis of antibody drug conjugates (ADCs).

(4-NH2)-Exatecan
Other Forms of (4-NH2)-Exatecan:
(R)-(4-NH2)-ExatecanT87720
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(4-NH2)-Exatecan

🥰Excellent
Purity: 99.89%
Catalog No. T40159Cas No. 2495742-21-5
(4-NH2)-Exatecan is a topoisomerase inhibitor with potential anticancer activity for the synthesis of antibody drug conjugates (ADCs).
Pack SizePriceAvailabilityQuantity
1 mg$123In Stock
5 mg$297In Stock
10 mg$496In Stock
25 mg$745In Stock
50 mg$987In Stock
100 mg$1,450In Stock
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This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.
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Batch Information

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Purity:99.89%
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COA HNMR HPLC

Product Introduction

Bioactivity
Description
(4-NH2)-Exatecan is a topoisomerase inhibitor with potential anticancer activity for the synthesis of antibody drug conjugates (ADCs).
Chemical Properties
Molecular Weight403.43
FormulaC23H21N3O4
Cas No.2495742-21-5
SmilesCC[C@@]1(O)C(=O)OCc2c1cc1-c3nc4ccc(N)c5CCCc(c3Cn1c2=O)c45
Relative Density.1.53 g/cm3 (Predicted)
Storage & Solubility Information
Storagekeep away from direct sunlight,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 80 mg/mL (198.3 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.4787 mL12.3937 mL24.7874 mL123.9372 mL
5 mM0.4957 mL2.4787 mL4.9575 mL24.7874 mL
10 mM0.2479 mL1.2394 mL2.4787 mL12.3937 mL
20 mM0.1239 mL0.6197 mL1.2394 mL6.1969 mL
50 mM0.0496 mL0.2479 mL0.4957 mL2.4787 mL
100 mM0.0248 mL0.1239 mL0.2479 mL1.2394 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
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Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

TopoADCCytotoxinADC Cytotoxin(4-NH2)-Exatecan(4-NH-2)-Exatecan(4NH2)Exatecan(4 NH2) Exatecan
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