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PROTAC PD-1/PD-L1 degrader-1
🥰Excellent
Catalog No. T40112Cas No. 2447066-37-5
PROTAC PD-1/PD-L1 degrader-1, a Cereblon E3 ligand-based compound, is a PD-1/PD-L1 PROTAC that effectively inhibits the PD-1/PD-L1 interaction with an IC50 of 39.2 nM. It restores the suppressed immune response in a co-culture model of Hep3B/OS-8/hPD-L1 cells and CD3 T cells and moderately decreases PD-L1 protein levels through a lysosome-dependent mechanism.
PROTAC PD-1/PD-L1 degrader-1
🥰Excellent
Purity: 99.07%
Catalog No. T40112Cas No. 2447066-37-5
PROTAC PD-1/PD-L1 degrader-1, a Cereblon E3 ligand-based compound, is a PD-1/PD-L1 PROTAC that effectively inhibits the PD-1/PD-L1 interaction with an IC50 of 39.2 nM. It restores the suppressed immune response in a co-culture model of Hep3B/OS-8/hPD-L1 cells and CD3 T cells and moderately decreases PD-L1 protein levels through a lysosome-dependent mechanism.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $253 | In Stock | |
| 5 mg | $619 | In Stock | |
| 10 mg | $987 | In Stock | |
| 25 mg | $1,520 | In Stock | |
| 50 mg | $1,980 | In Stock | |
| 100 mg | $2,770 | In Stock | |
| 200 mg | $3,730 | In Stock |
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Purity:99.07%
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Product Introduction
Bioactivity
Chemical Properties
| Description | PROTAC PD-1/PD-L1 degrader-1, a Cereblon E3 ligand-based compound, is a PD-1/PD-L1 PROTAC that effectively inhibits the PD-1/PD-L1 interaction with an IC50 of 39.2 nM. It restores the suppressed immune response in a co-culture model of Hep3B/OS-8/hPD-L1 cells and CD3 T cells and moderately decreases PD-L1 protein levels through a lysosome-dependent mechanism. |
| In vitro | PROTAC PD-1/PD-L1 degrader-1 (compound p22) significantly reduces PD-L1 expression on the cell surface by over 14%[1]. When administered at 1-10 μM for 24 hours, it decreases PD-L1 levels dose-dependently, with reductions of 21% and 35% at 1 μM and 10 μM, respectively[1]. Western Blot Analysis in MDA-MB-231 cell lines confirmed its efficacy in modulating PD-L1 expression at these dosages[1]. |
| Molecular Weight | 1076.59 |
| Formula | C59H58ClN7O11 |
| Cas No. | 2447066-37-5 |
| Smiles | N#CC1=CC=CC(=C1)COC2=CC(OCC3=CC=CC(C4=CC=C5OCCOC5=C4)=C3C)=C(Cl)C=C2CN6CCCCC6C(=O)N7CCN(C(=O)CCCC(=O)NC8=CC=CC=9C(=O)N(C(=O)C89)C%10C(=O)NC(=O)CC%10)CC7 |
| Relative Density. | 1.45 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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