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PROTAC PD-1/PD-L1 degrader-1
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Catalog No. T40112Cas No. 2447066-37-5
PROTAC PD-1/PD-L1 degrader-1, a Cereblon E3 ligand-based compound, is a PD-1/PD-L1 PROTAC that effectively inhibits the PD-1/PD-L1 interaction with an IC50 of 39.2 nM. It restores the suppressed immune response in a co-culture model of Hep3B/OS-8/hPD-L1 cells and CD3 T cells and moderately decreases PD-L1 protein levels through a lysosome-dependent mechanism.
PROTAC PD-1/PD-L1 degrader-1
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Purity: 99.07%
Catalog No. T40112Cas No. 2447066-37-5
PROTAC PD-1/PD-L1 degrader-1, a Cereblon E3 ligand-based compound, is a PD-1/PD-L1 PROTAC that effectively inhibits the PD-1/PD-L1 interaction with an IC50 of 39.2 nM. It restores the suppressed immune response in a co-culture model of Hep3B/OS-8/hPD-L1 cells and CD3 T cells and moderately decreases PD-L1 protein levels through a lysosome-dependent mechanism.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $253 | In Stock | In Stock | |
| 5 mg | $619 | In Stock | In Stock | |
| 10 mg | $987 | - | In Stock | |
| 25 mg | $1,520 | - | In Stock | |
| 50 mg | $1,980 | - | In Stock | |
| 100 mg | $2,770 | - | In Stock | |
| 200 mg | $3,730 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.07%
Appearance:Solid
Color:Yellow
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Product Introduction
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Chemical Properties
Storage & Solubility Information
| Description | PROTAC PD-1/PD-L1 degrader-1, a Cereblon E3 ligand-based compound, is a PD-1/PD-L1 PROTAC that effectively inhibits the PD-1/PD-L1 interaction with an IC50 of 39.2 nM. It restores the suppressed immune response in a co-culture model of Hep3B/OS-8/hPD-L1 cells and CD3 T cells and moderately decreases PD-L1 protein levels through a lysosome-dependent mechanism. |
| In vitro | PROTAC PD-1/PD-L1 degrader-1 (compound p22) significantly reduces PD-L1 expression on the cell surface by over 14%[1]. When administered at 1-10 μM for 24 hours, it decreases PD-L1 levels dose-dependently, with reductions of 21% and 35% at 1 μM and 10 μM, respectively[1]. Western Blot Analysis in MDA-MB-231 cell lines confirmed its efficacy in modulating PD-L1 expression at these dosages[1]. |
| Molecular Weight | 1076.59 |
| Formula | C59H58ClN7O11 |
| Cas No. | 2447066-37-5 |
| Smiles | N#CC1=CC=CC(=C1)COC2=CC(OCC3=CC=CC(C4=CC=C5OCCOC5=C4)=C3C)=C(Cl)C=C2CN6CCCCC6C(=O)N7CCN(C(=O)CCCC(=O)NC8=CC=CC=9C(=O)N(C(=O)C89)C%10C(=O)NC(=O)CC%10)CC7 |
| Relative Density. | 1.45 g/cm3 (Predicted) |
| Storage | store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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