Powder: -20°C for 3 years | In solvent: -80°C for 1 year
PROTAC PD-1/PD-L1 degrader-1, a Cereblon E3 ligand-based compound, is a PD-1/PD-L1 PROTAC that effectively inhibits the interaction between PD-1 and PD-L1 with an IC50 value of 39.2 nM. It successfully restores the suppressed immune response in a co-culture model consisting of Hep3B/OS-8/hPD-L1 cells and CD3 T cells. Additionally, this compound moderately decreases PD-L1 protein levels through a lysosome-dependent mechanism.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | Inquiry | $ 727.00 | |
10 mg | Inquiry | $ 1,160.00 | |
50 mg | Inquiry | Inquiry | |
100 mg | Inquiry | Inquiry |
Description | PROTAC PD-1/PD-L1 degrader-1, a Cereblon E3 ligand-based compound, is a PD-1/PD-L1 PROTAC that effectively inhibits the interaction between PD-1 and PD-L1 with an IC50 value of 39.2 nM. It successfully restores the suppressed immune response in a co-culture model consisting of Hep3B/OS-8/hPD-L1 cells and CD3 T cells. Additionally, this compound moderately decreases PD-L1 protein levels through a lysosome-dependent mechanism. |
In vitro | PROTAC PD-1/PD-L1 degrader-1 (compound p22) is shown to diminish PD-L1 expression on the cell surface by more than 14%[1]. When applied at concentrations ranging from 1-10 μM for 24 hours, it notably decreases PD-L1 levels in a dose-dependent fashion, with reductions of 21% and 35% observed at 1 μM and 10 μM concentrations, respectively[1]. This effect was validated through Western Blot Analysis using MDA-MB-231 cell lines, corroborating the compound’s efficacy in modulating PD-L1 expression at specified dosages[1]. |
Synonyms | PROTAC PD-1/PD-L1 degrader-1 |
Molecular Weight | 1076.6 |
Formula | C59H58ClN7O11 |
CAS No. | 2447066-37-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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PROTAC PD-1/PD-L1 degrader-1 2447066-37-5 PROTAC PD 1/PD L1 degrader 1 PROTAC PD1/PDL1 degrader1 PROTAC PD-1/PD-L-1 degrader-1 inhibitor inhibit