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TRPC6-PAM-C20

Name: TRPC6-PAM-C20
Brand: TargetMol
SKU: T37428
Price: 178 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T37428Cas No. 667427-75-0

Alias TRPC6-PAM-C20, 3-(6,7-Dimethoxy-3,3-dimethyl-3,4-dihydro-isoquinolin-1-yl)-chromen-2-one

TRPC6-PAM-C20 is a selective TRPC6 positive allosteric modulator that induces a transient increase in intracellular Ca2+ with an EC50 of 2.37 μM in HEK cells expressing TRPC6 and enhances OAG-induced platelet aggregation.

TRPC6-PAM-C20

🥰Excellent

Purity: 98.16%

Catalog No. T37428Alias TRPC6-PAM-C20, 3-(6,7-Dimethoxy-3,3-dimethyl-3,4-dihydro-isoquinolin-1-yl)-chromen-2-oneCas No. 667427-75-0

Pack Size	Price	Availability
1 mg	$178	In Stock
5 mg	$455	In Stock
10 mg	$672	In Stock
25 mg	$1,060	In Stock
50 mg	$1,430	In Stock
1 mL x 10 mM (in DMSO)	$490	In Stock

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Batch Information

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Purity:98.16%

Resource Download

COA HPLC

Product Introduction

Bioactivity

Description	TRPC6-PAM-C20 is a selective TRPC6 positive allosteric modulator that induces a transient increase in intracellular Ca2+ with an EC50 of 2.37 μM in HEK cells expressing TRPC6 and enhances OAG-induced platelet aggregation.
Targets&IC50	TRPC6 (HEK293 cells):2.37 μM (EC50)
Synonyms	TRPC6-PAM-C20, 3-(6,7-Dimethoxy-3,3-dimethyl-3,4-dihydro-isoquinolin-1-yl)-chromen-2-one

Chemical Properties

Molecular Weight	363.41
Formula	C₂₂H₂₁NO₄
Cas No.	667427-75-0
Smiles	COc1cc2CC(C)(C)N=C(c2cc1OC)c1cc2ccccc2oc1=O
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 90 mg/mL (247.65 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7517 mL	13.7586 mL	27.5171 mL	137.5856 mL
5 mM	0.5503 mL	2.7517 mL	5.5034 mL	27.5171 mL
10 mM	0.2752 mL	1.3759 mL	2.7517 mL	13.7586 mL
20 mM	0.1376 mL	0.6879 mL	1.3759 mL	6.8793 mL
50 mM	0.0550 mL	0.2752 mL	0.5503 mL	2.7517 mL
100 mM	0.0275 mL	0.1376 mL	0.2752 mL	1.3759 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc