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TRPC6-PAM-C20

Name: TRPC6-PAM-C20
Brand: TargetMol
SKU: T37428
Price: 178 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T37428Cas No. 667427-75-0

Alias TRPC6-PAM-C20, 3-(6,7-Dimethoxy-3,3-dimethyl-3,4-dihydro-isoquinolin-1-yl)-chromen-2-one

TRPC6-PAM-C20 is a selective TRPC6 positive allosteric modulator that induces a transient increase in intracellular Ca2+ with an EC50 of 2.37 μM in HEK cells expressing TRPC6 and enhances OAG-induced platelet aggregation.

TRPC6-PAM-C20

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Purity: 98.16%

Catalog No. T37428Alias TRPC6-PAM-C20, 3-(6,7-Dimethoxy-3,3-dimethyl-3,4-dihydro-isoquinolin-1-yl)-chromen-2-oneCas No. 667427-75-0

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$178	-	In Stock
5 mg	$455	-	In Stock
10 mg	$672	-	In Stock
25 mg	$1,060	-	In Stock
50 mg	$1,430	-	In Stock
1 mL x 10 mM (in DMSO)	$490	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.16%

Appearance:Solid

Color:White

Resource Download

COA HPLC

Product Introduction

Bioactivity

Description	TRPC6-PAM-C20 is a selective TRPC6 positive allosteric modulator that induces a transient increase in intracellular Ca2+ with an EC50 of 2.37 μM in HEK cells expressing TRPC6 and enhances OAG-induced platelet aggregation.
Targets&IC50	TRPC6 (HEK293 cells):2.37 μM (EC50)
Synonyms	TRPC6-PAM-C20, 3-(6,7-Dimethoxy-3,3-dimethyl-3,4-dihydro-isoquinolin-1-yl)-chromen-2-one

Chemical Properties

Molecular Weight	363.41
Formula	C₂₂H₂₁NO₄
Cas No.	667427-75-0
Smiles	COc1cc2CC(C)(C)N=C(c2cc1OC)c1cc2ccccc2oc1=O

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 90 mg/mL (247.65 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7517 mL	13.7586 mL	27.5171 mL	137.5856 mL
5 mM	0.5503 mL	2.7517 mL	5.5034 mL	27.5171 mL
10 mM	0.2752 mL	1.3759 mL	2.7517 mL	13.7586 mL
20 mM	0.1376 mL	0.6879 mL	1.3759 mL	6.8793 mL
50 mM	0.0550 mL	0.2752 mL	0.5503 mL	2.7517 mL
100 mM	0.0275 mL	0.1376 mL	0.2752 mL	1.3759 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc