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5-hydroxytryptophan

Name: 5-hydroxytryptophan
Brand: TargetMol
SKU: T3003
Price: 50 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T3003Cas No. 56-69-9

Alias NSC-92523

5-Hydroxytryptophan (NSC-92523) is a metabolite of tryptophan and a direct precursor of serotonin. It is a substrate of aromatic amino acid decarboxylase and can be used to induce depression models.

5-hydroxytryptophan

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Purity: 99.52%

Catalog No. T3003Alias NSC-92523Cas No. 56-69-9

5-Hydroxytryptophan (NSC-92523) is a metabolite of tryptophan and a direct precursor of serotonin. It is a substrate of aromatic amino acid decarboxylase and can be used to induce depression models.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
20 mg	$50	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$50	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:99.52%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	5-Hydroxytryptophan (NSC-92523) is a metabolite of tryptophan and a direct precursor of serotonin. It is a substrate of aromatic amino acid decarboxylase and can be used to induce depression models.
In vitro	5-Hydroxytryptophan exhibits toxicity in mice with an LD50 of 1800 mg/kg. In rats, it demonstrates effects at a dosage of 300 mg/kg when administered intragastrically (i.g.).
In vivo	5-Hydroxytryptophan is an intermediate in the biosynthesis of serotonin from the essential amino acid L-tryptophan, which can easily cross the blood-brain barrier and effectively increase the synthesis of serotonin within the central nervous system. It has been shown to improve conditions such as depression, chronic headaches, and insomnia.
Synonyms	NSC-92523

Chemical Properties

Molecular Weight	220.22
Formula	C₁₁H₁₂N₂O₃
Cas No.	56-69-9
Smiles	NC(CC1=CNC2=CC=C(O)C=C12)C(O)=O
Relative Density.	1.484

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (272.45 mM), Sonication is recommended.

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

H2O: 4 mg/mL (18.16 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (9.08 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	4.5409 mL	22.7046 mL	45.4091 mL	227.0457 mL
5 mM	0.9082 mL	4.5409 mL	9.0818 mL	45.4091 mL
10 mM	0.4541 mL	2.2705 mL	4.5409 mL	22.7046 mL

DMSO

	1mg	5mg	10mg	50mg
20 mM	0.2270 mL	1.1352 mL	2.2705 mL	11.3523 mL
50 mM	0.0908 mL	0.4541 mL	0.9082 mL	4.5409 mL
100 mM	0.0454 mL	0.2270 mL	0.4541 mL	2.2705 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc