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DR2313

Name: DR2313
Brand: TargetMol
SKU: T22749
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T22749Cas No. 284028-90-6

Alias DR 2313

DR2313 is a competitive inhibitor of poly(ADP-ribose) polymerase (IC50: 0.20 and 0.24 μM for PARP-1 and PARP-2 respectively). It also has neuroprotective.

DR2313

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Purity: 98.65%

Catalog No. T22749Alias DR 2313Cas No. 284028-90-6

DR2313 is a competitive inhibitor of poly(ADP-ribose) polymerase (IC50: 0.20 and 0.24 μM for PARP-1 and PARP-2 respectively). It also has neuroprotective.

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$29	In Stock	In Stock
10 mg	$48	In Stock	In Stock
25 mg	$98	In Stock	In Stock
50 mg	$148	In Stock	In Stock
100 mg	$173	In Stock	In Stock
200 mg	$257	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:98.65%

Appearance:Solid

Color:Orange

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	DR2313 is a competitive inhibitor of poly(ADP-ribose) polymerase (IC50: 0.20 and 0.24 μM for PARP-1 and PARP-2 respectively). It also has neuroprotective.
Targets&IC50	PARP2:0.24 μM, PARP1:0.20 μM
In vitro	DR 2313 decreases neuronal cell death in models of cerebral ischemia in vivo and in vitro.
In vivo	In both permanent and transient focal ischemia models in rats, pretreatment with DR2313 (10 mg/kg i.v. bolus and 10 mg/kg/h i.v. infusion for 6 h) significantly reduced the cortical infarct volume.?To determine the therapeutic time window of neuroprotection by DR2313, the effect of post-treatment was examined in transient focal ischemia model and compared with that of a free radical scavenger, MCI-186 (3-methyl-1-phenyl-2-pyrazolone-5-one).?Pretreatment with MCI-186 (3 mg/kg i.v. bolus and 3 mg/kg/h i.v. infusion for 6 h) significantly reduced the infarct volume, whereas the post-treatment failed to show any effects.?In contrast, post-treatment with DR2313 (same regimen) delaying for 2 h after ischemia still prevented the progression of infarction.?These results indicate that DR2313 exerts neuroprotective effects via its potent PARP inhibition, even when the treatment is initiated after ischemia.?Thus, a PARP inhibitor like DR2313 may be more useful in treating acute stroke than a free radical scavenger[1].
Synonyms	DR 2313

Chemical Properties

Molecular Weight	182.24
Formula	C₈H₁₀N₂OS
Cas No.	284028-90-6
Smiles	Cc1nc(=O)c2CSCCc2[nH]1
Relative Density.	1.463g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 18.33 mg/mL (100.58 mM), Sonication is recommended.

H2O: 9.1 mg/mL (49.93 mM), Sonication is recommended.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	5.4873 mL	27.4363 mL	54.8727 mL	274.3635 mL
5 mM	1.0975 mL	5.4873 mL	10.9745 mL	54.8727 mL
10 mM	0.5487 mL	2.7436 mL	5.4873 mL	27.4363 mL
20 mM	0.2744 mL	1.3718 mL	2.7436 mL	13.7182 mL

DMSO

	1mg	5mg	10mg	50mg
50 mM	0.1097 mL	0.5487 mL	1.0975 mL	5.4873 mL
100 mM	0.0549 mL	0.2744 mL	0.5487 mL	2.7436 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc