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Anti-DR4/TRAIL R1 Antibody (6F81)

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Catalog No. TMAY-00778
Alias tumor necrosis factor receptor superfamily member 10a, TRAILR-1, TRAILR1, TNFRSF10A, MGC9365, DR4, CD261, APO2

Anti-DR4/TRAIL R1 Antibody (6F81) is a Mouse antibody targeting DR4/TRAIL R1. Anti-DR4/TRAIL R1 Antibody (6F81) can be used in ELISA(Cap),FCM.

Anti-DR4/TRAIL R1 Antibody (6F81)

Anti-DR4/TRAIL R1 Antibody (6F81)

😃Good
Catalog No. TMAY-00778Alias tumor necrosis factor receptor superfamily member 10a, TRAILR-1, TRAILR1, TNFRSF10A, MGC9365, DR4, CD261, APO2
Anti-DR4/TRAIL R1 Antibody (6F81) is a Mouse antibody targeting DR4/TRAIL R1. Anti-DR4/TRAIL R1 Antibody (6F81) can be used in ELISA(Cap),FCM.
Pack SizePriceAvailabilityQuantity
20 μL$70 7-10 days
100 μL$199 7-10 days
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Product Introduction

Bioactivity
Description
Anti-DR4/TRAIL R1 Antibody (6F81) is a Mouse antibody targeting DR4/TRAIL R1. Anti-DR4/TRAIL R1 Antibody (6F81) can be used in ELISA(Cap),FCM.
Aliastumor necrosis factor receptor superfamily member 10a, TRAILR-1, TRAILR1, TNFRSF10A, MGC9365, DR4, CD261, APO2
Ig Type
Monoclonal Mouse IgG1
Clone
6F81
Reactivity
Human
Verified Activity
Flow cytometric analysis of Human TNFRSF10A(CD261) expression on HeLa cells. Cells were stained with purified anti-Human TNFRSF10A(CD261), then a FITC-conjugated second step antibody. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells.
Application
ELISA(Cap),FCM
Recommended Dose
FCM: 1:25-1:100; ELISA(Cap): 1:250-1:2000
Antibody Type
Monoclonal
Host SpeciesMouse
ConstructionThis antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human TRAIL R1 / CD261 / TNFRSF10A (rh TRAIL R1 / CD261 / TNFRSF10A; TMPY-01720; NP_003835.2; Met1-Asn239). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
PurificationProtein A
AppearanceLiquid
Formulation0.2 μm filtered solution in PBS
Research BackgroundTumor necrosis factor receptor superfamily, member 10a (TRAIL R1), also known as TRAIL receptor 1 (TRAIL R1) or CD261 antigen, is a member of the TNF-receptor superfamily. This receptor is activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL), and thus transduces cell death signal and induces cell apoptosis. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. TRAIL R1/CD261/TNFRSF10A serves as a receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. TRAIL R1 can promote the activation of NF-kappa-B. TRAIL R1/CD261/TNFRSF10A induces apoptosis of many transformed cell lines but not of normal tissues, even though its death domain-containing receptor, DR4, is expressed on both cell types.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy
Related Conjugates and Formulations
Conjucates
Unconjugated
Others Formats
FITC/PE
Antibody Types Available
3
Antigen Details
Immunogen
Recombinant Human TRAIL R1 / CD261 / TNFRSF10A Protein (TMPY-01720)
Antigen Species
Human
Biology Area
Cancer Drug Targets
Chemical Properties
Stability & Storage
Stability & StorageStore at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free.
TransportShipping with blue ice.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

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