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XIAP-CASP7 PPI-IN-1

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Catalog No. T211590

XIAP-CASP7 PPI-IN-1 is a reversible inhibitor of the XIAP:CASP7 interaction, effectively disrupting the connection between XIAP and CASP7. It selectively induces apoptosis in MCF-7 and caspase-3 low-expression (CASP3/DR) triple-negative breast cancer cells. The compound overcomes chemoresistance by down-regulating β-catenin and associated ABC transporters in paclitaxel-resistant MCF-7 cells. XIAP-CASP7 PPI-IN-1 is useful for breast cancer research.

XIAP-CASP7 PPI-IN-1

XIAP-CASP7 PPI-IN-1

😃Good
Catalog No. T211590
XIAP-CASP7 PPI-IN-1 is a reversible inhibitor of the XIAP:CASP7 interaction, effectively disrupting the connection between XIAP and CASP7. It selectively induces apoptosis in MCF-7 and caspase-3 low-expression (CASP3/DR) triple-negative breast cancer cells. The compound overcomes chemoresistance by down-regulating β-catenin and associated ABC transporters in paclitaxel-resistant MCF-7 cells. XIAP-CASP7 PPI-IN-1 is useful for breast cancer research.
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Product Introduction

Bioactivity
Description
XIAP-CASP7 PPI-IN-1 is a reversible inhibitor of the XIAP:CASP7 interaction, effectively disrupting the connection between XIAP and CASP7. It selectively induces apoptosis in MCF-7 and caspase-3 low-expression (CASP3/DR) triple-negative breast cancer cells. The compound overcomes chemoresistance by down-regulating β-catenin and associated ABC transporters in paclitaxel-resistant MCF-7 cells. XIAP-CASP7 PPI-IN-1 is useful for breast cancer research.
In vitro
XIAP-CASP7 PPI-IN-1 (Compound 643943) exhibits the highest cytotoxicity against MCF-7 cells at concentrations of 0-50 μM over 4-24 hours, mediated by apoptotic signaling. It binds to CASP7 via Asp93 at 0-0.5 nM μM over 24 hours, releasing active CASP7 from XIAP and inducing cell death. Additionally, at 1.25-5 μM over 24 hours, it acts synergistically with anticancer drugs, sensitizing Paclitaxel-resistant MCF-7 cells (7TR) to chemotherapy.
In vivo
The compound XIAP-CASP7 PPI-IN-1 (Compound 643943), administered at a dosage of 20 mg/kg intraperitoneally once daily for 2 weeks, exhibits antitumor activity in a mouse model of breast cancer.
Chemical Properties
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
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