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Eltoprazine hydrochloride

Name: Eltoprazine hydrochloride
Brand: TargetMol
SKU: T7498
Price: 40 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T7498Cas No. 98206-09-8

Alias DU 28853 hydrochloride

Eltoprazine hydrochloride (DU 28853 hydrochloride) is a partial agonist at serotonin 5-HT1A, 5-HT1B, and 5-HT2B receptors (Ki value of 40, 52, and 81 nM, respectively).

Eltoprazine hydrochloride

🥰Excellent

Purity: 99.35%

Catalog No. T7498Alias DU 28853 hydrochlorideCas No. 98206-09-8

Eltoprazine hydrochloride (DU 28853 hydrochloride) is a partial agonist at serotonin 5-HT1A, 5-HT1B, and 5-HT2B receptors (Ki value of 40, 52, and 81 nM, respectively).

Pack Size	Price	Availability
5 mg	$40	In Stock
10 mg	$73	In Stock
25 mg	$147	In Stock
50 mg	$272	In Stock
100 mg	$396	In Stock
500 mg	$927	In Stock
1 mL x 10 mM (in DMSO)	$44	In Stock

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Bulk & Custom

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Purity:99.35%

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	Eltoprazine hydrochloride (DU 28853 hydrochloride) is a partial agonist at serotonin 5-HT1A, 5-HT1B, and 5-HT2B receptors (Ki value of 40, 52, and 81 nM, respectively).
Targets&IC50	5-HT1A:40 nM , 5-HT2B:81 nM, 5-HT1B:52 nM
In vivo	Eltoprazine hydrochloride exerts a dose-dependent decrease in aggressive behavior in resident-intruder tests with rats (ID50 = 0.24 mg/kg)[1].
Synonyms	DU 28853 hydrochloride

Chemical Properties

Molecular Weight	256.73
Formula	C₁₂H₁₇ClN₂O₂
Cas No.	98206-09-8
Smiles	Cl.c1cc2c(c(N3CCNCC3)c1)OCCO2
Relative Density.	1.18g/cm3
Color	Yellow
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 31 mg/mL (120.75 mM), Sonication is recommended.

H2O: 28 mg/mL (109.06 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (7.79 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	3.8951 mL	19.4757 mL	38.9514 mL	194.7571 mL
5 mM	0.7790 mL	3.8951 mL	7.7903 mL	38.9514 mL
10 mM	0.3895 mL	1.9476 mL	3.8951 mL	19.4757 mL
20 mM	0.1948 mL	0.9738 mL	1.9476 mL	9.7379 mL
50 mM	0.0779 mL	0.3895 mL	0.7790 mL	3.8951 mL
100 mM	0.0390 mL	0.1948 mL	0.3895 mL	1.9476 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc