Shopping Cart

Your shopping cart is currently empty

Proceed to checkout Continue shopping

ODQ

Copy Product Info

😃Good

Catalog No. T19777Cas No. 41443-28-1

ODQ is an effective and selective soluble guanylyl cyclase (sGC) inhibitor.

ODQ

Copy Product Info

😃Good

Purity: 98.98%

Catalog No. T19777Cas No. 41443-28-1

ODQ is an effective and selective soluble guanylyl cyclase (sGC) inhibitor.

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$42	-	In Stock
5 mg	$68	-	In Stock
10 mg	$101	-	In Stock
25 mg	$153	-	In Stock
50 mg	$231	-	In Stock
100 mg	$346	-	In Stock
200 mg	$519	-	In Stock
500 mg	$843	Inquiry	Inquiry
1 mL x 10 mM (in DMSO)	$65	-	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:98.98%

Appearance:Solid

Color:Yellow

Resource Download

COA HNMR HPLC

Product Introduction

ODQ AI Summary

ODQ inhibits soluble guanylyl cyclase in rat aortic smooth muscle cells with an 85% inhibition of SNP-stimulated cGMP formation at 0.1 μM concentration. It exhibits antiplasmodial activity against Plasmodium falciparum strains GB4 and HB3, with IC50 values of 10,000 nM and 7,943.28 nM, respectively, after 72 hours using the SYBR green assay. Additionally, ODQ shows a broad spectrum of bioactivities including modulation of NFkB signaling, inhibition of various enzymes and proteins involved in Plasmodium proliferation, HSD17B4, JMJD2E, mitochondrial dynamics, and tau fibril formation among others. It also demonstrates antiviral activity by inhibiting SARS-CoV-2 induced cytotoxicity in Caco-2 and VERO-6 cells at 10 μM concentration and an inhibitory effect on SARS-CoV-2 3CL-Pro protease at 20 μM. Furthermore, ODQ shows variable inhibitory activity on human HDAC6 enzyme with a slight increase when tested with a custom peptide substrate..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

ODQ is an effective and selective soluble guanylyl cyclase (sGC) inhibitor.

Chemical Properties

Molecular Weight	187.15
Formula	C₉H₅N₃O₂
Cas No.	41443-28-1
Smiles	O=c1onc2cnc3ccccc3n12
Relative Density.	1.61 g/cm3

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (534.33 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 5 mg/mL (26.72 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	5.3433 mL	26.7165 mL	53.4331 mL	267.1654 mL
5 mM	1.0687 mL	5.3433 mL	10.6866 mL	53.4331 mL
10 mM	0.5343 mL	2.6717 mL	5.3433 mL	26.7165 mL
20 mM	0.2672 mL	1.3358 mL	2.6717 mL	13.3583 mL
50 mM	0.1069 mL	0.5343 mL	1.0687 mL	5.3433 mL
100 mM	0.0534 mL	0.2672 mL	0.5343 mL	2.6717 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc