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PF-07284892

Name: PF-07284892
Brand: TargetMol
SKU: T79123
Price: 61 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T79123Cas No. 2498597-94-5

Alias PF07284892, ARRY-558, ARRY558

PF-07284892 (ARRY-558) is an orally active allosteric SHP2 inhibitor (IC50 = 21 nM) that reduces pERK expression and may be employed in solid tumour research.

PF-07284892

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Purity: 97.77%

Catalog No. T79123Alias PF07284892, ARRY-558, ARRY558Cas No. 2498597-94-5

PF-07284892 (ARRY-558) is an orally active allosteric SHP2 inhibitor (IC50 = 21 nM) that reduces pERK expression and may be employed in solid tumour research.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$61	-	In Stock
5 mg	$147	-	In Stock
10 mg	$198	-	In Stock
25 mg	$413	-	In Stock
50 mg	$645	-	In Stock
1 mL x 10 mM (in DMSO)	$162	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:97.77%

Appearance:Solid

Color:Yellow

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	PF-07284892 (ARRY-558) is an orally active allosteric SHP2 inhibitor (IC50 = 21 nM) that reduces pERK expression and may be employed in solid tumour research.
Targets&IC50	SHP2:21 nM
In vitro	PF-07284892 (100 nM; 4, 18 h), in combination with lorlatinib (0-450 nM) or binimetinib (0-160 nM), reduces pERK expression in H3122 lorR-06 and VACO-432 cells.[2]
In vivo	After oral administration of 10 mg/kg PF-07284892, the compound exhibited oral bioavailability of 85%, 94%, 102%, and 64% in mice, rats, dogs, and monkeys respectively, demonstrating favorable oral absorption. [2]
Synonyms	PF07284892, ARRY-558, ARRY558

Chemical Properties

Molecular Weight	439.96
Formula	C₂₁H₂₂ClN₇S
Cas No.	2498597-94-5
Smiles	N[C@H]1C2(CC=3C1=CC=CC3)CCN(CC2)C=4N=CC(SC=5C(Cl)=C(N)N=CC5)=NN4

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (181.83 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 3.3 mg/mL (7.5 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2729 mL	11.3647 mL	22.7293 mL	113.6467 mL
5 mM	0.4546 mL	2.2729 mL	4.5459 mL	22.7293 mL
10 mM	0.2273 mL	1.1365 mL	2.2729 mL	11.3647 mL
20 mM	0.1136 mL	0.5682 mL	1.1365 mL	5.6823 mL
50 mM	0.0455 mL	0.2273 mL	0.4546 mL	2.2729 mL
100 mM	0.0227 mL	0.1136 mL	0.2273 mL	1.1365 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

PF-07284892

PF-07284892

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In Vivo Formulation Calculator (Clear solution)

Dose Conversion

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