Powder: -20°C for 3 years | In solvent: -80°C for 1 year
PF-07284892 (ARRY-558) is an orally active, potent inhibitor of SHP2, demonstrating an IC50 of 21 nM, and is known to reduce the expression of pERK [1] [2].
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 8-10 weeks | $ 1,520.00 | |
50 mg | 8-10 weeks | $ 1,980.00 | |
100 mg | 8-10 weeks | $ 2,500.00 |
Description | PF-07284892 (ARRY-558) is an orally active, potent inhibitor of SHP2, demonstrating an IC50 of 21 nM, and is known to reduce the expression of pERK [1] [2]. |
In vitro | PF-07284892 (100 nM; 4, 18 h) in combination with lorlatinib (0-450 nM) or binimetinib (0-160 nM) reduces the expression of pERK in H3122 lorR-06 and VACO-432 cells [2]. |
In vivo | PF-07284892 (10 mg/kg; p.o.) demonstrated high oral bioavailability, with F% values of 85%, 94%, 102%, and 64% in mice, rats, dogs, and monkeys, respectively [2]. |
Synonyms | ARRY-558 |
Molecular Weight | 439.96 |
Formula | C21H22ClN7S |
CAS No. | 2498597-94-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
PF-07284892 2498597-94-5 ARRY-558 inhibitor inhibit