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PF-07284892

🥰Excellent
Catalog No. T79123Cas No. 2498597-94-5
Alias PF07284892, ARRY-558, ARRY558

PF-07284892 (ARRY-558) is an orally active allosteric SHP2 inhibitor (IC50 = 21 nM) that reduces pERK expression and may be employed in solid tumour research.

PF-07284892

PF-07284892

🥰Excellent
Purity: 97.77%
Catalog No. T79123Alias PF07284892, ARRY-558, ARRY558Cas No. 2498597-94-5
PF-07284892 (ARRY-558) is an orally active allosteric SHP2 inhibitor (IC50 = 21 nM) that reduces pERK expression and may be employed in solid tumour research.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$61-In Stock
5 mg$147-In Stock
10 mg$198-In Stock
25 mg$413-In Stock
50 mg$645-In Stock
1 mL x 10 mM (in DMSO)$162-In Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Purity:97.77%
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Product Introduction

Bioactivity
Description
PF-07284892 (ARRY-558) is an orally active allosteric SHP2 inhibitor (IC50 = 21 nM) that reduces pERK expression and may be employed in solid tumour research.
Targets&IC50
SHP2:21 nM
In vitro
PF-07284892 (100 nM; 4, 18 h), in combination with lorlatinib (0-450 nM) or binimetinib (0-160 nM), reduces pERK expression in H3122 lorR-06 and VACO-432 cells.[2]
In vivo
After oral administration of 10 mg/kg PF-07284892, the compound exhibited oral bioavailability of 85%, 94%, 102%, and 64% in mice, rats, dogs, and monkeys respectively, demonstrating favorable oral absorption. [2]
SynonymsPF07284892, ARRY-558, ARRY558
Chemical Properties
Molecular Weight439.96
FormulaC21H22ClN7S
Cas No.2498597-94-5
SmilesN[C@H]1C2(CC=3C1=CC=CC3)CCN(CC2)C=4N=CC(SC=5C(Cl)=C(N)N=CC5)=NN4
ColorYellow
AppearanceSolid
Storage & Solubility Information
Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 80 mg/mL (181.83 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween-80+45% Saline: 3.3 mg/mL (7.5 mM), Sonication is recommeded.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.2729 mL11.3647 mL22.7293 mL113.6467 mL
5 mM0.4546 mL2.2729 mL4.5459 mL22.7293 mL
10 mM0.2273 mL1.1365 mL2.2729 mL11.3647 mL
20 mM0.1136 mL0.5682 mL1.1365 mL5.6823 mL
50 mM0.0455 mL0.2273 mL0.4546 mL2.2729 mL
100 mM0.0227 mL0.1136 mL0.2273 mL1.1365 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
% DMSO
%
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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