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GDC-0927

Name: GDC-0927
Brand: TargetMol
SKU: T11380
Rating: 4.5 (1 reviews)

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Catalog No. T11380Cas No. 1642297-01-5

Alias SRN-927

GDC-0927 is a novel,non-steroidal, potent, orally bioavailable, selective estrogen receptor antagonist.

GDC-0927

😃Good

Catalog No. T11380Alias SRN-927Cas No. 1642297-01-5

GDC-0927 is a novel,non-steroidal, potent, orally bioavailable, selective estrogen receptor antagonist.

Pack Size	Price	USA Warehouse	Global Warehouse
10 mg	$747	7-10 days	7-10 days
25 mg	$1,610	7-10 days	7-10 days
50 mg	$2,570	7-10 days	7-10 days

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	GDC-0927 is a novel,non-steroidal, potent, orally bioavailable, selective estrogen receptor antagonist.
In vivo	GDC-0927, a novel and potent non-steroidal, orally bioavailable selective estrogen receptor (ER) antagonist/degrader (SERD), effectively induces tumor regression in patient-derived xenograft models of estrogen receptor-positive (ER+) breast cancer (BC).
Synonyms	SRN-927

Chemical Properties

Molecular Weight	461.52
Formula	C₂₈H₂₈FNO₄
Cas No.	1642297-01-5
Relative Density.	1.257 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 83.33 mg/mL (180.56 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 3.3 mg/mL (7.15 mM), Sonication is recommeded.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1668 mL	10.8338 mL	21.6675 mL	108.3377 mL
5 mM	0.4334 mL	2.1668 mL	4.3335 mL	21.6675 mL
10 mM	0.2167 mL	1.0834 mL	2.1668 mL	10.8338 mL
20 mM	0.1083 mL	0.5417 mL	1.0834 mL	5.4169 mL
50 mM	0.0433 mL	0.2167 mL	0.4334 mL	2.1668 mL
100 mM	0.0217 mL	0.1083 mL	0.2167 mL	1.0834 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc