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RO-275
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Catalog No. T87339Cas No. 2648837-04-9
Alias RO275
RO-275 is a selective HCN1 inhibitor with oral activity, also inhibiting HCN2, HCN3, and HCN4. It improves working memory and is used in research on cognitive disorders.
RO-275
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Purity: 98.3%
Catalog No. T87339Alias RO275Cas No. 2648837-04-9
RO-275 is a selective HCN1 inhibitor with oral activity, also inhibiting HCN2, HCN3, and HCN4. It improves working memory and is used in research on cognitive disorders.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $165 | In Stock | In Stock | |
| 5 mg | $413 | In Stock | In Stock | |
| 10 mg | $662 | - | In Stock | |
| 25 mg | $1,060 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Purity:98.3%
Appearance:Solid
Color:White to Yellow
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | RO-275 is a selective HCN1 inhibitor with oral activity, also inhibiting HCN2, HCN3, and HCN4. It improves working memory and is used in research on cognitive disorders. |
| Targets&IC50 | HCN1:0.046 µM, HCN3:4.6 µM, HCN4:13.9 µM, HCN2:14.3 µM |
| In vitro | RO-275 (compound 29) is a potent, selective and orally active HCN1 inhibitor with IC50 values of 0.046, 14.3, 4.6 and 13.9 µM for HCN1, HCN2, HCN3 and HCN4, respectively. [1] |
| In vivo | RO-275 (3, 10 and 30 mg/kg, intraperitoneally injected) can save the reduction of working memory in rats. [1] |
| Synonyms | RO275 |
| Molecular Weight | 351.79 |
| Formula | C18H14ClN5O |
| Cas No. | 2648837-04-9 |
| Smiles | O=C(N)C1=NC(C#CC=2C=CN=C(Cl)C2C)=C(N1C=3C=NC=CC3)C |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||
| Solubility Information | DMSO: 4 mg/mL (11.37 mM), Sonication and heating are recommended. | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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