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Urolithin E

🥰Excellent
Catalog No. TN11617Cas No. 1453297-45-4

Urolithin E is a secondary metabolite produced by the gut microbiota from ellagitannins and ellagic acid. As a member of the urolithin family, it features a polyhydroxylated dibenzopyran-6-one skeleton. Research indicates that Urolithin E possesses significant antioxidant and anti-inflammatory activities, capable of scavenging free radicals and inhibiting oxidative stress-induced cellular damage. Furthermore, as a bioactive metabolite, it has demonstrated potential biological functions in modulating apoptosis and inhibiting the proliferation of specific cancer cell lines.

Urolithin E

Urolithin E

🥰Excellent
Catalog No. TN11617Cas No. 1453297-45-4
Urolithin E is a secondary metabolite produced by the gut microbiota from ellagitannins and ellagic acid. As a member of the urolithin family, it features a polyhydroxylated dibenzopyran-6-one skeleton. Research indicates that Urolithin E possesses significant antioxidant and anti-inflammatory activities, capable of scavenging free radicals and inhibiting oxidative stress-induced cellular damage. Furthermore, as a bioactive metabolite, it has demonstrated potential biological functions in modulating apoptosis and inhibiting the proliferation of specific cancer cell lines.
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Product Introduction

Bioactivity
Description
Urolithin E is a secondary metabolite produced by the gut microbiota from ellagitannins and ellagic acid. As a member of the urolithin family, it features a polyhydroxylated dibenzopyran-6-one skeleton. Research indicates that Urolithin E possesses significant antioxidant and anti-inflammatory activities, capable of scavenging free radicals and inhibiting oxidative stress-induced cellular damage. Furthermore, as a bioactive metabolite, it has demonstrated potential biological functions in modulating apoptosis and inhibiting the proliferation of specific cancer cell lines.
In vitro
In antioxidant assays, Urolithin E demonstrated potent radical scavenging activity (e.g., DPPH and ABTS assays), exhibiting a higher antioxidant capacity compared to its less hydroxylated counterparts like Urolithin A and B. It effectively reduced intracellular reactive oxygen species (ROS) levels in challenged cell models [1].
In vivo
Upon oral administration of ellagitannin-rich foods, Urolithin E can be detected in biological fluids (plasma and urine) as a phase II metabolite (glucuronide or sulfate conjugate), reflecting its bioavailability and systemic distribution after gut microbial transformation [2].
Chemical Properties
Molecular Weight260.2
FormulaC13H8O6
Cas No.1453297-45-4
SmilesO=C1OC=2C(O)=C(O)C=CC2C3=C(O)C=C(O)C=C13
Relative Density.no data available
Storage & Solubility Information
Storagestore at low temperature,keep away from direct sunlight | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
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2 Enter the in vivo formulation:
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

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