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MKC-1

Name: MKC-1
Brand: TargetMol
SKU: T9831
Price: 654 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T9831Cas No. 125313-92-0

Alias Ro-31-7453

MKC-1 (Ro-31-7453) is an orally bioavailable small-molecule bisindolylmaleimide cell cycle inhibitor with potential antineoplastic activity. MKC-1 and its metabolites inhibit tubulin polymerization, blocking mitotic spindle formation, which may result in apoptosis and tumor cell death.

MKC-1

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Purity: 99.85%

Catalog No. T9831Alias Ro-31-7453Cas No. 125313-92-0

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$52	In Stock	In Stock
5 mg	$127	In Stock	In Stock
10 mg	$187	In Stock	In Stock
25 mg	$325	In Stock	In Stock
50 mg	$469	In Stock	In Stock
100 mg	$654	In Stock	In Stock
500 mg	Preferential	-	In Stock
1 mL x 10 mM (in DMSO)	$136	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.85%

Appearance:Solid

Color:Red

Resource Download

COA HNMR LCMS

Product Introduction

MKC-1 AI Summary

MKC-1 inhibits rat brain protein kinase C (PKC) using ATP and histone as substrates, with an IC50 value of 1100 nM..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	MKC-1 (Ro-31-7453) is an orally bioavailable small-molecule bisindolylmaleimide cell cycle inhibitor with potential antineoplastic activity. MKC-1 and its metabolites inhibit tubulin polymerization, blocking mitotic spindle formation, which may result in apoptosis and tumor cell death.
Synonyms	Ro-31-7453

Chemical Properties

Molecular Weight	400.39
Formula	C₂₂H₁₆N₄O₄
Cas No.	125313-92-0
Smiles	Cn1cc(C2=C(C(=O)NC2=O)c2cn(C)c3cc(ccc23)[N+]([O-])=O)c2ccccc12

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (137.37 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4976 mL	12.4878 mL	24.9756 mL	124.8782 mL
5 mM	0.4995 mL	2.4976 mL	4.9951 mL	24.9756 mL
10 mM	0.2498 mL	1.2488 mL	2.4976 mL	12.4878 mL
20 mM	0.1249 mL	0.6244 mL	1.2488 mL	6.2439 mL
50 mM	0.0500 mL	0.2498 mL	0.4995 mL	2.4976 mL
100 mM	0.0250 mL	0.1249 mL	0.2498 mL	1.2488 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc