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Anti-TIMP-1 Antibody (2N677)

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Catalog No. TMAY-01349
Alias TIMP metallopeptidase inhibitor 1

Anti-TIMP-1 Antibody (2N677) is a Rabbit antibody targeting TIMP-1. Anti-TIMP-1 Antibody (2N677) can be used in ELISA.

Anti-TIMP-1 Antibody (2N677)

Anti-TIMP-1 Antibody (2N677)

😃Good
Catalog No. TMAY-01349Alias TIMP metallopeptidase inhibitor 1
Anti-TIMP-1 Antibody (2N677) is a Rabbit antibody targeting TIMP-1. Anti-TIMP-1 Antibody (2N677) can be used in ELISA.
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20 μL$93 7-10 days
100 μL$269 7-10 days
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Product Introduction

Bioactivity
Description
Anti-TIMP-1 Antibody (2N677) is a Rabbit antibody targeting TIMP-1. Anti-TIMP-1 Antibody (2N677) can be used in ELISA.
AliasTIMP metallopeptidase inhibitor 1
Ig Type
Monoclonal Rabbit IgG
Clone
2N677
Reactivity
Human
Application
ELISA
Recommended Dose
ELISA: 1:5000-1:10000
Antibody Type
Monoclonal
Host SpeciesRabbit
ConstructionThis antibody was obtained from a rabbit immunized with purified, recombinant Human TIMP1 (rh TIMP1; TMPY-00932; NP_003245.1; Met 1-Ala 207).
PurificationProtein A
AppearanceLiquid
Formulation0.2 μm filtered solution in PBS
Research BackgroundTIMP metallopeptidase inhibitor 1, also known as TIMP-1/TIMP1, Collagenase inhibitor 16C8 fibroblast Erythroid-potentiating activity, TPA-S1TPA-induced proteinTissue inhibitor of metalloproteinases 1, is a natural inhibitors of the matrix metalloproteinases (MMPs), a group of peptidases involved in degradation of the extracellular matrix. TIMP-1/TIMP1 is found in fetal and adult tissues. Highest levels are found in bone, lung, ovary and uterus. Complexes with metalloproteinases and irreversibly inactivates them by binding to their catalytic zinc cofactor. TIMP-1/TIMP1 mediates erythropoiesis in vitro; but, unlike IL-3, it is species-specific, stimulating the growth and differentiation of only human and murine erythroid progenitors. In addition to its inhibitory role against most of the known MMPs, the protein is able to promote cell proliferation in a wide range of cell types, and may also have an anti-apoptotic function. Transcription of this protein encoding gene is highly inducible in response to many cytokines and hormones. In addition, the expression from some but not all inactive X chromosomes suggests that this gene inactivation is polymorphic in human females. This encoding gene is located within intron 6 of the synapsin I gene and is transcribed in the opposite direction. Complexes with metalloproteinases and irreversibly inactivates them by binding to their catalytic zinc cofactor. TIMP-1/TIMP1 is Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-11, MMP-12, MMP-13 and MMP-16.
Related Conjugates and Formulations
Conjucates
Unconjugated
Antigen Details
Immunogen
Recombinant Human TIMP1 protein (TMPY-00932)
Antigen Species
Human
Chemical Properties
Stability & Storage
Stability & StorageStore at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free.
TransportShipping with blue ice.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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