keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
m3-Huwentoxin IV (m3-HwTx-IV) is a potent inhibitor of sodium channels (NaV), exhibiting half-maximal inhibitory concentrations (IC50s) of 3.3 nM for hNaV1.7, 6.8 nM for hNaV1.6, 7.2 nM for hNaV1.3, 8.4 nM for hNaV1.1, 11.9 nM for hNaV1.2, and 369 nM for hNaV1.4 in the QPatch assay. It also dose-dependently alleviates spontaneous pain in a rodent model when induced by the NaV1.7 activator OD1 [1].
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Description | m3-Huwentoxin IV (m3-HwTx-IV) is a potent inhibitor of sodium channels (NaV), exhibiting half-maximal inhibitory concentrations (IC50s) of 3.3 nM for hNaV1.7, 6.8 nM for hNaV1.6, 7.2 nM for hNaV1.3, 8.4 nM for hNaV1.1, 11.9 nM for hNaV1.2, and 369 nM for hNaV1.4 in the QPatch assay. It also dose-dependently alleviates spontaneous pain in a rodent model when induced by the NaV1.7 activator OD1 [1]. |
Synonyms | m3-HwTx-IV |
Molecular Weight | 3985.69 |
Formula | C170H271N53O46S6 |
keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. More
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m3-Huwentoxin IV Membrane transporter/Ion channel Sodium Channel m3-HwTx-IV inhibitor inhibit