Shopping Cart

Remove All
Your shopping cart is currently empty

IU1-248

Name: IU1-248
Brand: TargetMol
SKU: T9375
Price: 43 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T9375Cas No. 2307472-03-1

IU1-248 is a derivative of IU1. IU1-248 is a potent and selective USP14 inhibitor with an IC50 of 0.83 μM[1].

IU1-248

🥰Excellent

Purity: 99.3%

Catalog No. T9375Cas No. 2307472-03-1

IU1-248 is a derivative of IU1. IU1-248 is a potent and selective USP14 inhibitor with an IC50 of 0.83 μM[1].

Pack Size	Price	Availability
1 mg	$43	In Stock
5 mg	$98	In Stock
10 mg	$163	In Stock
25 mg	$335	In Stock
50 mg	$472	In Stock
100 mg	$673	In Stock
200 mg	$939	In Stock
1 mL x 10 mM (in DMSO)	$109	In Stock

Add to Cart

Add to Quotation

Bulk & Custom

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:99.3%

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	IU1-248 is a derivative of IU1. IU1-248 is a potent and selective USP14 inhibitor with an IC50 of 0.83 μM[1].
Targets&IC50	USP14:0.83 μM
In vitro	IU1-248 exhibits an IC50 value of 0.83?μM toward USP14, which is 10-fold more potent than that of IU1 (IC50=12.25 μM)[1].

Chemical Properties

Molecular Weight	337.42
Formula	C₂₀H₂₃N₃O₂
Cas No.	2307472-03-1
Smiles	Cc1cc(C(=O)CN2CCC(O)CC2)c(C)n1-c1ccc(cc1)C#N
Relative Density.	1.20 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (237.09 mM), Sonication and heating to 60℃ are recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9637 mL	14.8183 mL	29.6367 mL	148.1833 mL
5 mM	0.5927 mL	2.9637 mL	5.9273 mL	29.6367 mL
10 mM	0.2964 mL	1.4818 mL	2.9637 mL	14.8183 mL
20 mM	0.1482 mL	0.7409 mL	1.4818 mL	7.4092 mL
50 mM	0.0593 mL	0.2964 mL	0.5927 mL	2.9637 mL
100 mM	0.0296 mL	0.1482 mL	0.2964 mL	1.4818 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc