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Clorgyline hydrochloride

Name: Clorgyline hydrochloride
Brand: TargetMol
SKU: T1117
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T1117Cas No. 17780-75-5

Alias Clorgiline hydrochloride

Clorgyline hydrochloride (Clorgiline hydrochloride), a white powder, is served as monoamine oxidase inhibitor.

Clorgyline hydrochloride

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Purity: 99.82%

Catalog No. T1117Alias Clorgiline hydrochlorideCas No. 17780-75-5

Clorgyline hydrochloride (Clorgiline hydrochloride), a white powder, is served as monoamine oxidase inhibitor.

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$30	In Stock	In Stock
10 mg	$45	In Stock	In Stock
25 mg	$55	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$52	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.82%

Color:White

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COA HNMR LCMS

Product Introduction

Clorgyline hydrochloride AI Summary

Clorgyline hydrochloride exhibits significant inhibitory activity against rat brain mitochondrial Monoamine Oxidase (MAO) with an IC50 value of 50000.0 nM and displays high selectivity with a concentration ratio for inhibiting MAO-A and MAO-B less than 0.01. It also shows antiplasmodial activity against Plasmodium falciparum 7G8, with an IC50 of 12589.25 nM after 72 hours as determined by SYBR green assay. Furthermore, Clorgyline hydrochloride demonstrates various bioactivities, including inhibition of Human Jumonji Domain Containing 2E (JMJD2E), MLL CXXC domain-DNA interaction, modulation of microRNA miR-21, inhibition of Tau fibril formation, hERG channel activity, and TGF-b cytotoxicity counterscreen. It affects the entry/binding of Lassa Virus, Ebola Virus, and SARS-CoV-2 infection in Vero E6 cells with an inhibition index of 0.3908. In addition, it inhibits ROR gamma transcriptional activity, supports Schwann cell viability, and shows implications in histone lysine methyltransferase G9a activity, ERK signaling, lipid storage modulation, APE1 endonuclease inhibition, ELG1-dependent DNA repair, chronic active B-cell receptor signaling, and firefly luciferase activity. Moreover, Clorgyline hydrochloride demonstrates antibiofilm activity against Candida albicans CAIF-100, with an MBIC50 of 24.0 µM as determined by the Cell-Titer Blue assay..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Clorgyline hydrochloride (Clorgiline hydrochloride), a white powder, is served as monoamine oxidase inhibitor.
Synonyms	Clorgiline hydrochloride

Chemical Properties

Molecular Weight	308.63
Formula	C₁₃H₁₅Cl₂NO·HCl
Cas No.	17780-75-5
Smiles	Cl.CN(CCCOc1ccc(Cl)cc1Cl)CC#C
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 4.17 mg/mL (13.51 mM), Sonication is recommended.

Ethanol: 100 mM, Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (3.24 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO/Ethanol

	1mg	5mg	10mg	50mg
1 mM	3.2401 mL	16.2006 mL	32.4013 mL	162.0063 mL
5 mM	0.6480 mL	3.2401 mL	6.4803 mL	32.4013 mL
10 mM	0.3240 mL	1.6201 mL	3.2401 mL	16.2006 mL

Ethanol

	1mg	5mg	10mg	50mg
20 mM	0.1620 mL	0.8100 mL	1.6201 mL	8.1003 mL
50 mM	0.0648 mL	0.3240 mL	0.6480 mL	3.2401 mL
100 mM	0.0324 mL	0.1620 mL	0.3240 mL	1.6201 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc