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[D-Pro4,D-Trp7,9] Substance P (4-11)

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Catalog No. T83495Cas No. 81039-85-2

[D-Pro4,D-Trp7,9] Substance P (4-11) acts as a potent Substance P antagonist, significantly reducing plasma aldosterone (ALDO) concentrations[1].

[D-Pro4,D-Trp7,9] Substance P (4-11)

[D-Pro4,D-Trp7,9] Substance P (4-11)

😃Good
Catalog No. T83495Cas No. 81039-85-2
[D-Pro4,D-Trp7,9] Substance P (4-11) acts as a potent Substance P antagonist, significantly reducing plasma aldosterone (ALDO) concentrations[1].
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Product Introduction

Bioactivity
Description
[D-Pro4,D-Trp7,9] Substance P (4-11) acts as a potent Substance P antagonist, significantly reducing plasma aldosterone (ALDO) concentrations[1].
In vivo
[D-Pro4, D-Trp7,9] Substance P (4-11) antagonizes the hypotensive and vasodilatory responses to Substance P in anesthetized rats and the perfused rabbit heart. Additionally, it inhibits Substance P-induced relaxation in noradrenaline-contracted dog carotid arteries and suppresses stimulatory effects in the guinea pig ileum and trachea [1]. When administered intraperitoneally at 0.3 nM/K/min for 7 days, it significantly reduces plasma aldosterone levels and induces atrophy in the zona glomerulosa and its parenchymal cells of the adrenal gland [2].
Chemical Properties
Molecular Weight1134.35
FormulaC57H75N13O10S
Cas No.81039-85-2
Sequence ShortPQQWFWLM-NH2
Storage & Solubility Information
Storagekeep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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