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[D-Pro4,D-Trp7,9] Substance P (4-11)

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Catalog No. T83495Cas No. 81039-85-2

[D-Pro4,D-Trp7,9] Substance P (4-11) acts as a potent Substance P antagonist, significantly reducing plasma aldosterone (ALDO) concentrations[1].

[D-Pro4,D-Trp7,9] Substance P (4-11)

[D-Pro4,D-Trp7,9] Substance P (4-11)

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Catalog No. T83495Cas No. 81039-85-2
[D-Pro4,D-Trp7,9] Substance P (4-11) acts as a potent Substance P antagonist, significantly reducing plasma aldosterone (ALDO) concentrations[1].
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Product Introduction

Bioactivity
Description
[D-Pro4,D-Trp7,9] Substance P (4-11) acts as a potent Substance P antagonist, significantly reducing plasma aldosterone (ALDO) concentrations[1].
In vivo
[D-Pro4, D-Trp7,9] Substance P (4-11) antagonizes the hypotensive and vasodilatory responses to Substance P in anesthetized rats and the perfused rabbit heart. Additionally, it inhibits Substance P-induced relaxation in noradrenaline-contracted dog carotid arteries and suppresses stimulatory effects in the guinea pig ileum and trachea [1]. When administered intraperitoneally at 0.3 nM/K/min for 7 days, it significantly reduces plasma aldosterone levels and induces atrophy in the zona glomerulosa and its parenchymal cells of the adrenal gland [2].
Chemical Properties
Molecular Weight1134.35
FormulaC57H75N13O10S
Cas No.81039-85-2
SmilesC([C@H](C(N[C@@H](CC1=CC=CC=C1)C(N[C@H](CC=2C=3C(NC2)=CC=CC3)C(N[C@H](C(N[C@@H](CCSC)C(N)=O)=O)CC(C)C)=O)=O)=O)NC([C@@H](NC([C@@H](NC(=O)[C@H]4CCCN4)CCC(N)=O)=O)CCC(N)=O)=O)C=5C=6C(NC5)=CC=CC6
SequenceH-D-Pro-Gln-Gln-D-Trp-Phe-D-Trp-Leu-Met-NH2
Sequence ShortPQQWFWLM
Storage & Solubility Information
Storagekeep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
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2 Enter the in vivo formulation:
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