keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
[D-Pro4,D-Trp7,9] Substance P (4-11) acts as a potent antagonist to Substance P, significantly reducing plasma aldosterone (ALDO) concentrations[1].
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Description | [D-Pro4,D-Trp7,9] Substance P (4-11) acts as a potent antagonist to Substance P, significantly reducing plasma aldosterone (ALDO) concentrations[1]. |
In vivo | [D-Pro4,D-Trp7,9] Substance P (4-11) antagonizes the hypotensive and vasodilatory responses to Substance P in anesthetized rats and in the perfused rabbit heart, respectively. Additionally, it inhibits Substance P-induced relaxation in noradrenaline-contracted dog carotid arteries, and supresses stimulatory effects in guinea pig ileum and trachea [1]. When administered intraperitoneally at 0.3 nM/K/min for 7 days, it significantly reduces plasma aldosterone levels and induces atrophy in both the zona glomerulosa and its parenchymal cells of the adrenal gland [2]. |
Molecular Weight | 1134.35 |
Formula | C57H75N13O10S |
CAS No. | 81039-85-2 |
keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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[D-Pro4,D-Trp7,9] Substance P (4-11) 81039-85-2 inhibitor inhibit