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Anti-RIPK1 Antibody (1B304)
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Catalog No. TMAC-03610
Alias RIPK1, RIP1, RIP, Receptor-interacting serine/threonine-protein kinase 1, Receptor-interacting protein 1 (RIP-1), Cell death protein RIP
Anti-RIPK1 Antibody (1B304) is a Rabbit antibody targeting RIPK1. Anti-RIPK1 Antibody (1B304) can be used in WB,FCM.
Anti-RIPK1 Antibody (1B304)
Anti-RIPK1 Antibody (1B304)
😃Good
Catalog No. TMAC-03610Alias RIPK1, RIP1, RIP, Receptor-interacting serine/threonine-protein kinase 1, Receptor-interacting protein 1 (RIP-1), Cell death protein RIP
Anti-RIPK1 Antibody (1B304) is a Rabbit antibody targeting RIPK1. Anti-RIPK1 Antibody (1B304) can be used in WB,FCM.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 50 μL | $298 | 7-10 days | |
| 100 μL | $497 | 7-10 days |
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Product Introduction
Bioactivity
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Antigen Details
Chemical Properties
| Description | Anti-RIPK1 Antibody (1B304) is a Rabbit antibody targeting RIPK1. Anti-RIPK1 Antibody (1B304) can be used in WB,FCM. |
| Synonyms | RIPK1, RIP1, RIP, Receptor-interacting serine/threonine-protein kinase 1, Receptor-interacting protein 1 (RIP-1), Cell death protein RIP |
| Ig Type | IgG |
| Reactivity | Human |
| Verified Activity | 1. Western blot analysis of RIP on Hela cells lysates using anti-RIP antibody at 1/1,000 dilution. 2. Flow cytometric analysis of 293 cells with RIP antibody at 1/50 dilution (red) compared with an unlabelled control (cells without incubation with primary antibody; black). Alexa Fluor 488-conjugated goat anti rabbit IgG was used as the secondary antibody. |
| Application | |
| Recommended Dose | WB: 1:1000-5000; FCM: 1:50-100 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | Recombinant Antibody |
| Purification | ProA affinity purified |
| Appearance | Liquid |
| Formulation | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
| Research Background | In contrast to growth factors which promote cell proliferation, FAS ligand (FAS-L) and the tumor necrosis factors (TNFs) rapidly induce apoptosis. Cellular response to FAS-L and TNF is mediated by structurally related receptors containing a conserved "death domain" and belonging to the TNF receptor superfamily. TRADD, FADD and RIP are FAS/TNF-R1 interacting proteins that contain a death domain homologous region (DDH). TRADD (TNF-R1-associated death domain) and FADD (FAS-associated death domain) associate with the death domains of both FAS and TNF-R1 via their DDH regions. Overexpression of TRADD leads to NFkB activation and apoptosis in the absence of TNF. Overexpression of FADD causes apoptosis, which can be blocked by the cow pox protein CrmA, suggesting that FADD lies upstream of ICE and possibly other serine proteases. The receptor interacting protein, RIP, associates with FAS exclusively via its DDH and this association is abrogated in lpr mutants. Unlike TRADD and FADD, RIP contains a putative amino terminal kinase domain. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Protein |
| Uniprot ID |
| Molecular Weight | Theoretical: 76 kDa. |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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