AXL Protein, Human, Recombinant (His)

Name: AXL Protein, Human, Recombinant (His)
Brand: TargetMol
SKU: TMPY-01601
Price: 136 USD
Availability: InStock
Rating: 5 (10 reviews)

(Synonyms: UFO, Tyro7, JTK11, AXL receptor tyrosine kinase, ARK) Copy Product Info

Synonyms: UFO, Tyro7, JTK11, AXL receptor tyrosine kinase, ARK

Catalog No. TMPY-01601 Copy Product Info

Purity: 97.9%

AXL Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 46.5 kDa and the accession number is AAB20305.1.

Pack Size	Price	USA Stock	Global Stock
5 µg	Preferential	-	In Stock
10 µg	$32	-	In Stock
20 µg	$47	-	In Stock
50 µg	$84	-	In Stock
100 µg	$136	-	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:97.9%

Appearance:Lyophilized powder

Color:White

Resource Download

COA User Guide of Recombinant Proteins

Product Information

Bioactivity

Bioactivity	Label GAS6 Protein, Mouse, Recombinant (His) (Cat: TMPY-04830) with biotin. Immobilized AXL Protein, Human, Recombinant (His) (Cat: TMPY-01601) at 0.25 μg/mL (100 μL/well) can bind biotinylated Recombinant Mouse GAS6 Protein, the EC50 is 1.3-3.9 ng/mL.
Description	AXL Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 46.5 kDa and the accession number is AAB20305.1.
Species	Human
Expression System	HEK293 Cells
Tag	C-His
Accession Number	AAB20305.1
Construction	A DNA sequence encoding the extracellular domain of human AXL isoform 1 (AAB20305.1) extracellular domain (Met1-Pro449) was fused with a polyhistidine tag at the C-terminus. Predicted N terminal: Glu 33
Protein Purity	> 98 % as determined by SDS-PAGE. > 90 % as determined by SEC-HPLC. ,
Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Formulation	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
Reconstitution	Reconstituted with sterile deionized water to 0.25 mg/mL. Reconstitution conditions may vary depending on the lot.
Synonyms	UFO, Tyro7, JTK11, AXL receptor tyrosine kinase, ARK
Research Background	Axl receptor tyrosine kinase, together with Tyro3 and Mer, constitute the TAM family of receptor tyrosine kinases. In the nervous system, Axl and its ligand Growth-arrest-specific protein 6 (Gas6) are expressed on multiple cell types. Axl functions in dampening the immune response, regulating cytokine secretion, clearing apoptotic cells and debris, and maintaining cell survival. Axl is upregulated in various disease states, such as in the cuprizone toxicity-induced model of demyelination and in multiple sclerosis (MS) lesions, suggesting that it plays a role in disease pathogenesis. Axl expression correlates with poor prognosis in several cancers. Axl mediates multiple oncogenic phenotypes and activation of these RTKs constitutes a mechanism of chemoresistance in a variety of solid tumors. Axl contributes to cell survival, migration, invasion, metastasis and chemosensitivity justify further investigation of Axl as novel therapeutic targets in cancer. The receptor tyrosine kinase AXL is thought to play a role in metastasis. The soluble AXL receptor as a therapeutic candidate agent for treatment of metastatic ovarian cancer. GAS6/AXL targeting as an effective strategy for inhibition of metastatic tumor progression in vivo.

Chemical Properties

Molecular Weight

46.5 kDa (predicted); 60-70 kDa (reducing condition, due to glycosylation)

Storage & Solubility Information

Shipping	In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.
Storage	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.