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MPP+ iodide

Name: MPP+ iodide
Brand: TargetMol
SKU: T9169
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T9169Cas No. 36913-39-0

MPP+ iodide, the metabolite of a neurotoxin MPTP, causes symptom of Parkinson's disease (PD) in animal models by selectively destroying dopaminergic neurons in substantia nigra. MPP+ induces dopamine transporter (DAT) externalization in dopaminergic (DA) neurons, but internalization of serotonin transporter (SERT) in serotonergic (5-HT) neurons. MPP+ induces autophagic cell death in SH-SY5Y cells.

MPP+ iodide

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Purity: 99.96%

Catalog No. T9169Cas No. 36913-39-0

Pack Size	Price	Availability
10 mg	$30	In Stock
25 mg	$63	In Stock
50 mg	$98	In Stock
100 mg	$163	In Stock
500 mg	$397	In Stock
1 mL x 10 mM (in DMSO)	$32	In Stock

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Purity:99.96%

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COA HPLC HNMR

Product Introduction

Bioactivity

Description	MPP+ iodide, the metabolite of a neurotoxin MPTP, causes symptom of Parkinson's disease (PD) in animal models by selectively destroying dopaminergic neurons in substantia nigra. MPP+ induces dopamine transporter (DAT) externalization in dopaminergic (DA) neurons, but internalization of serotonin transporter (SERT) in serotonergic (5-HT) neurons. MPP+ induces autophagic cell death in SH-SY5Y cells.
In vitro	METHODS: Human neuroblastoma cells SH-SY5Y were treated with MPP+ iodide (1-4 mM) for 12-48 h, and cell viability was detected using CCK-8 Assay.
In vivo	METHODS: To test for acute toxicity to embryonic or neonatal mice, MPP+ iodide (8.6-34.2 mg/kg) was injected intraperitoneally into pregnant or neonatal mice. RESULTS: Neurotoxicity induced by a single injection of MPP+ iodide was transient and recoverable in embryonic and neonatal mice. In contrast, no significant changes in MAO-A and MAO-B expression levels were observed in MPP+ iodide-treated mice. [3]

Chemical Properties

Molecular Weight	297.13
Formula	C₁₂H₁₂IN
Cas No.	36913-39-0
Smiles	[I-].C=1C=CC(=CC1)C=2C=C[N+](=CC2)C
Relative Density.	no data available

Storage & Solubility Information

Storage

keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 100 mg/mL (336.54 mM), Sonication is recommended.

DMSO: 135 mg/mL (454.35 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (13.46 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	3.3655 mL	16.8277 mL	33.6553 mL	168.2765 mL
5 mM	0.6731 mL	3.3655 mL	6.7311 mL	33.6553 mL
10 mM	0.3366 mL	1.6828 mL	3.3655 mL	16.8277 mL
20 mM	0.1683 mL	0.8414 mL	1.6828 mL	8.4138 mL
50 mM	0.0673 mL	0.3366 mL	0.6731 mL	3.3655 mL
100 mM	0.0337 mL	0.1683 mL	0.3366 mL	1.6828 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc