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CDK8-IN-4

Name: CDK8-IN-4
Brand: TargetMol
SKU: T17305
Rating: 4.5 (1 reviews)

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Catalog No. T17305Cas No. 1613638-82-6

CDK8-IN-4 (compound 16) is an effective CDK8 inhibitor (IC50=0.2 nM) for studying CDK8-related cancers.

CDK8-IN-4

😃Good

Catalog No. T17305Cas No. 1613638-82-6

CDK8-IN-4 (compound 16) is an effective CDK8 inhibitor (IC50=0.2 nM) for studying CDK8-related cancers.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
50 mg	$747	6-8 weeks	6-8 weeks
100 mg	$1,360	6-8 weeks	6-8 weeks

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Appearance:Solid

Color:White

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COA

Product Introduction

Bioactivity

Description	CDK8-IN-4 (compound 16) is an effective CDK8 inhibitor (IC50=0.2 nM) for studying CDK8-related cancers.
Targets&IC50	CDK8:0.2 nM

Chemical Properties

Molecular Weight	330.38
Formula	C₂₀H₁₈N₄O
Cas No.	1613638-82-6
Smiles	N([C@@H](CO)C1=CC=CC=C1)C2=CC(C=3C=C4C(=CC3)NN=C4)=CN=C2
Relative Density.	1.329 g/cm3 (Predicted)

Storage & Solubility Information

Storage

keep away from moisture,keep away from direct sunlight | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (242.15 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.0268 mL	15.1341 mL	30.2682 mL	151.3409 mL
5 mM	0.6054 mL	3.0268 mL	6.0536 mL	30.2682 mL
10 mM	0.3027 mL	1.5134 mL	3.0268 mL	15.1341 mL
20 mM	0.1513 mL	0.7567 mL	1.5134 mL	7.5670 mL
50 mM	0.0605 mL	0.3027 mL	0.6054 mL	3.0268 mL
100 mM	0.0303 mL	0.1513 mL	0.3027 mL	1.5134 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc