Popular Searches
Diphenyleneiodonium chlorideEpacadostatGilteritinibDinaciclibRo-3306
TargetMol | Star Product
Wikimole
TargetMol | New Product
New Product
TargetMol | Compound Library
Compound Library
Contact Us
Shopping Cart
  • Remove All
  • TargetMol
    Your shopping cart is currently empty
TOPRelated productsBioactivityChemical infoStorage&SolubilityCalculator

Defensin HNP-1, human acetate

🥰Excellent
Catalog No. T41135L
Alias Defensin HNP-1, human acetate（99287-08-8 Free base）

Defensin HNP-1, human acetate is an antimicrobial peptide and human α -defensin found mainly in neutrophils with broad-spectrum antimicrobial activity against bacteria and viruses, triggers NF-κB and IRF1 thereby increasing IFN-α, induces apoptosis in tumor cells, inhibits vascular endothelial cell function, mediates immunity to infections and more.

Defensin HNP-1, human acetate

Defensin HNP-1, human acetate

🥰Excellent
Catalog No. T41135LAlias Defensin HNP-1, human acetate（99287-08-8 Free base）
Defensin HNP-1, human acetate is an antimicrobial peptide and human α -defensin found mainly in neutrophils with broad-spectrum antimicrobial activity against bacteria and viruses, triggers NF-κB and IRF1 thereby increasing IFN-α, induces apoptosis in tumor cells, inhibits vascular endothelial cell function, mediates immunity to infections and more.
TargetMol
Product information is being updated, if you want to purchase, please click the bulk custom button.
Bulk & Custom
Questions
View More
Contact us for more batch information
Resource Download
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Product Introduction

Bioactivity
Description
Defensin HNP-1, human acetate is an antimicrobial peptide and human α -defensin found mainly in neutrophils with broad-spectrum antimicrobial activity against bacteria and viruses, triggers NF-κB and IRF1 thereby increasing IFN-α, induces apoptosis in tumor cells, inhibits vascular endothelial cell function, mediates immunity to infections and more.
In vitro
Defensin HNP-1, human acetate (2.5 μg/mL for 48 h) inhibits the growth of human ovarian cancer cell line SKOV3 and induces apoptosis, likely through cell cycle arrest and activation of pro-apoptotic proteins such as caspase-3. Defensin HNP-1, human acetate has also been shown to sensitize cancer cells to chemotherapeutic agents like paclitaxel[1].
In vivo
In vivo, in a xenograft model using nude mice (subcutaneous SKOV3 tumors), Defensin HNP-1, human acetate (10 μg/mouse, intraperitoneally, three times per week for 3 weeks) significantly suppressed tumor volume compared to control (P<0.05)[1].
AliasDefensin HNP-1, human acetate（99287-08-8 Free base）
Chemical Properties
Molecular Weight3508.13
FormulaC152H232N44O40S6
SmilesOC(C)=O.OC(C=C1)=CC=C1C[C@H](NC([C@H]([C@@H](C)CC)NC([C@H](CS)NC([C@H]([C@H](O)C)NC(CNC([C@@H](NC([C@H](CCCNC(N)=N)NC([C@H](CCCNC(N)=N)NC([C@H](CCC(O)=O)NC(CNC([C@H](C)NC([C@H]([C@@H](C)CC)NC([C@H](CS)NC([C@H](C)NC([C@H]2N(CCC2)C([C@H]([C@@H](C)CC)NC([C@H](CCCNC(N)=N)NC([C@H](CS)NC([C@@H](NC([C@H](CS)NC([C@@H](N)C)=O)=O)CC3=CC=C(C=C3)O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)CC4=CC=C(C=C4)O)=O)=O)=O)=O)=O)C(N[C@@H](CCC(N)=O)C(NCC(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC(C)C)C(N[C@H](C(N[C@@H](C)C(N[C@H](C(N[C@@H](CS)C(N[C@@H](CS)C(O)=O)=O)=O)CC5=CC=CC=C5)=O)=O)CC6=CNC7=CC=CC=C67)=O)=O)=O)=O)=O
Storage & Solubility Information
Storagekeep away from moisture | store at -20°C | Shipping with blue ice/Shipping at ambient temperature.

Sci Citations

Calculator

  • Molarity Calculator
  • Dilution Calculator
  • Reconstitution Calculator
  • Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Related Tags: buy Defensin HNP-1, human acetate | purchase Defensin HNP-1, human acetate | Defensin HNP-1, human acetate cost | order Defensin HNP-1, human acetate | Defensin HNP-1, human acetate chemical structure | Defensin HNP-1, human acetate in vivo | Defensin HNP-1, human acetate in vitro | Defensin HNP-1, human acetate formula | Defensin HNP-1, human acetate molecular weight
TargetMol | Logo

Copyright © 2015-2025 TargetMol Chemicals Inc. All Rights Reserved.