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Iptacopan

Iptacopan (LNP023) is an inhibitor with high affinity for factor B.

Catalog No. T11864Cas No. 1644670-37-0

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Purity:100%

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COA HNMR HPLC

Iptacopan

Catalog No. T11864Cas No. 1644670-37-0

Iptacopan (LNP023) is an inhibitor with high affinity for factor B.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Pack Size	Price	Availability
1 mg	$132	In Stock
5 mg	$328	In Stock
10 mg	$563	In Stock
25 mg	$995	In Stock
50 mg	$1,580	In Stock
100 mg	$2,390	In Stock
500 mg	$4,820	In Stock
1 mL x 10 mM (in DMSO)	$363	In Stock

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Product Introduction

Bioactivity

Description	Iptacopan (LNP023) is an inhibitor with high affinity for factor B.
Targets&IC50	DPP4:> 100 μM, Cathepsin S:> 30 μM, Cathepsin B:> 100 μM, Cathepsin H:> 100 μM, Cathepsin K:> 100 μM, Caspase-1:> 100 μM, FB:7.9 nM (KD), FB:10 nM, CFB:0.01 μM, 5-LOX:> 30 μM, Apopain:> 100 μM, COX-2 receptor:> 30 μM, Chymase:> 100 μM, Cathepsin G:> 100 μM, CFB:0.012 μM, DPP2:> 100 μM, Blood-coagulation factor Xa:> 100 μM, COX-1 receptor:> 30 μM, Caspase-8:> 100 μM, Cathepsin L:48 μM, Chymotrypsin:> 100 μM
Alias	LNP023

Chemical Properties

Molecular Weight	422.52
Formula	C₂₅H₃₀N₂O₄
Cas No.	1644670-37-0

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 55 mg/mL (130.17 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3668 mL	11.8338 mL	23.6675 mL	118.3376 mL
5 mM	0.4734 mL	2.3668 mL	4.7335 mL	23.6675 mL
10 mM	0.2367 mL	1.1834 mL	2.3668 mL	11.8338 mL
20 mM	0.1183 mL	0.5917 mL	1.1834 mL	5.9169 mL
50 mM	0.0473 mL	0.2367 mL	0.4734 mL	2.3668 mL
100 mM	0.0237 mL	0.1183 mL	0.2367 mL	1.1834 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

LNP 023LNP-023Iptacopan