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BMS-779788

Name: BMS-779788
Brand: TargetMol
SKU: T3970
Price: 35 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T3970Cas No. 918348-67-1

Alias XL-652, XL652, XL 652, EXEL04286652, BMS-788

BMS-779788 (XL-652) is an LXRα/β partial agonist (IC50: 68/14 nM).

BMS-779788

🥰Excellent

Purity: 99.24%

Catalog No. T3970Alias XL-652, XL652, XL 652, EXEL04286652, BMS-788Cas No. 918348-67-1

BMS-779788 (XL-652) is an LXRα/β partial agonist (IC50: 68/14 nM).

Pack Size	Price	Availability
2 mg	$35	In Stock
5 mg	$54	In Stock
10 mg	$81	In Stock
25 mg	$159	In Stock
50 mg	$263	In Stock
1 mL x 10 mM (in DMSO)	$62	In Stock

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This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Purity:99.24%

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Product Introduction

Bioactivity

Description	BMS-779788 (XL-652) is an LXRα/β partial agonist (IC50: 68/14 nM).
Targets&IC50	LXRα:68nM, LXRβ:14 nM
In vitro	BMS-779788 can effectively induce ATP binding transporters ABCA1 and ABCG1 in the human whole blood (EC50: 1.2 μM).
In vivo	BMS-779788 has an inducted effect of LXR target genes in blood in vivo (EC50: 610 nM). In elevating plasma triglyceride and LDL cholesterol, BMS-779788 is 29- and 12-fold less potent than the full agonist T0901317 respectively[1]. In mice, BMS-779788 displayed peripheral induction of ABCA1 at 3 and 10mpk doses with no significant elevation of plasma or hepatic triglycerides at these doses, showing an improved profile compared to a full pan-agonist[2].
Synonyms	XL-652, XL652, XL 652, EXEL04286652, BMS-788

Chemical Properties

Molecular Weight	509.06
Formula	C₂₈H₂₉ClN₂O₃S
Cas No.	918348-67-1
Smiles	CC(C)(O)c1cn(c(n1)C(C)(C)c1ccccc1Cl)-c1ccc(cc1)-c1cccc(c1)S(C)(=O)=O
Relative Density.	1.21 g/cm3 (Predicted)
Color	Yellow
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (117.86 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9644 mL	9.8220 mL	19.6440 mL	98.2202 mL
5 mM	0.3929 mL	1.9644 mL	3.9288 mL	19.6440 mL
10 mM	0.1964 mL	0.9822 mL	1.9644 mL	9.8220 mL
20 mM	0.0982 mL	0.4911 mL	0.9822 mL	4.9110 mL
50 mM	0.0393 mL	0.1964 mL	0.3929 mL	1.9644 mL
100 mM	0.0196 mL	0.0982 mL	0.1964 mL	0.9822 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc