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BMS-779788

Name: BMS-779788
Brand: TargetMol
SKU: T3970
Price: 33 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T3970Cas No. 918348-67-1

Alias XL-652, XL652, XL 652, EXEL04286652, BMS-788

BMS-779788 (XL-652) is an LXRα/β partial agonist (IC50: 68/14 nM).

BMS-779788

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Purity: 99.24%

Catalog No. T3970Alias XL-652, XL652, XL 652, EXEL04286652, BMS-788Cas No. 918348-67-1

BMS-779788 (XL-652) is an LXRα/β partial agonist (IC50: 68/14 nM).

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$33	In Stock	In Stock
5 mg	$51	In Stock	In Stock
10 mg	$77	In Stock	In Stock
25 mg	$151	In Stock	In Stock
50 mg	$250	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$59	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.24%

Color:White to Yellow

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COA

Product Introduction

Bioactivity

Description	BMS-779788 (XL-652) is an LXRα/β partial agonist (IC50: 68/14 nM).
Targets&IC50	LXRβ:14 nM, LXRα:68nM
In vitro	BMS-779788 can effectively induce ATP binding transporters ABCA1 and ABCG1 in the human whole blood (EC50: 1.2 μM).
In vivo	BMS-779788 has an inducted effect of LXR target genes in blood in vivo (EC50: 610 nM). In elevating plasma triglyceride and LDL cholesterol, BMS-779788 is 29- and 12-fold less potent than the full agonist T0901317 respectively[1]. In mice, BMS-779788 displayed peripheral induction of ABCA1 at 3 and 10mpk doses with no significant elevation of plasma or hepatic triglycerides at these doses, showing an improved profile compared to a full pan-agonist[2].
Synonyms	XL-652, XL652, XL 652, EXEL04286652, BMS-788

Chemical Properties

Molecular Weight	509.06
Formula	C₂₈H₂₉ClN₂O₃S
Cas No.	918348-67-1
Smiles	CC(C)(O)c1cn(c(n1)C(C)(C)c1ccccc1Cl)-c1ccc(cc1)-c1cccc(c1)S(C)(=O)=O
Relative Density.	1.21 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (117.86 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 2.5 mg/mL (4.91 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9644 mL	9.8220 mL	19.6440 mL	98.2202 mL
5 mM	0.3929 mL	1.9644 mL	3.9288 mL	19.6440 mL
10 mM	0.1964 mL	0.9822 mL	1.9644 mL	9.8220 mL
20 mM	0.0982 mL	0.4911 mL	0.9822 mL	4.9110 mL
50 mM	0.0393 mL	0.1964 mL	0.3929 mL	1.9644 mL
100 mM	0.0196 mL	0.0982 mL	0.1964 mL	0.9822 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc