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PROTAC BRD9 Degrader-1

Name: PROTAC BRD9 Degrader-1
Brand: TargetMol
SKU: T12560
Rating: 4.5 (1 reviews)

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Catalog No. T12560Cas No. 2097971-01-0

PROTAC BRD9 Degrader-1 is a leading PROTAC BRD9 chemical degrader with an IC50 of 13.5 nM.

PROTAC BRD9 Degrader-1

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Catalog No. T12560Cas No. 2097971-01-0

PROTAC BRD9 Degrader-1 is a leading PROTAC BRD9 chemical degrader with an IC50 of 13.5 nM.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
5 mg	$733	Inquiry	Inquiry
10 mg	$1,219	Inquiry	Inquiry

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	PROTAC BRD9 Degrader-1 is a leading PROTAC BRD9 chemical degrader with an IC50 of 13.5 nM.
Targets&IC50	BRD4:3.78 μM, CRBN-DDB1:48.9 nM, BRD9:13.5 nM
In vitro	PROTAC BRD9 Degrader-1 inhibits BRD9, BRD4, and CRBN-DDB1 (IC50s = 13.5 nM, 3.78 μM, and 48.9 nM, respectively)[1].

Chemical Properties

Molecular Weight	903.98
Formula	C₄₂H₄₅N₇O₁₂S₂
Cas No.	2097971-01-0
Smiles	O=C(NCCCCNC(=O)COC1=CC=CC=2C(=O)N(C(=O)C12)C3C(=O)NC(=O)CC3)COC=4C=CC(=CC4OC)C5=CN(C(=O)C=6C=C(SC65)C(=N)NC7CCS(=O)(=O)CC7)C
Relative Density.	1.56 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 150 mg/mL (165.93 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 3.3 mg/mL (3.65 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.1062 mL	5.5311 mL	11.0622 mL	55.3110 mL
5 mM	0.2212 mL	1.1062 mL	2.2124 mL	11.0622 mL
10 mM	0.1106 mL	0.5531 mL	1.1062 mL	5.5311 mL
20 mM	0.0553 mL	0.2766 mL	0.5531 mL	2.7655 mL
50 mM	0.0221 mL	0.1106 mL	0.2212 mL	1.1062 mL
100 mM	0.0111 mL	0.0553 mL	0.1106 mL	0.5531 mL

Calculator

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc