Shopping Cart

Your shopping cart is currently empty

WIN 18446

Name: WIN 18446
Brand: TargetMol
SKU: T23533
Price: 34 USD
Availability: InStock
Rating: 5 (10 reviews)

Copy Product Info

😃Good

Catalog No. T23533Cas No. 1477-57-2

inhibitor of aldehyde dehydrogenase 1a2 (ALDH1a2)

WIN 18446

Copy Product Info

😃Good

Purity: 99.69%

Catalog No. T23533Cas No. 1477-57-2

inhibitor of aldehyde dehydrogenase 1a2 (ALDH1a2)

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$34	In Stock	In Stock
50 mg	$48	In Stock	In Stock
100 mg	$73	In Stock	In Stock
500 mg	$176	In Stock	-
1 g	$262	Inquiry	Inquiry
1 mL x 10 mM (in DMSO)	$50	In Stock	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:99.69%

Appearance:Solid

Color:Yellow

Resource Download

COA HNMR LCMS HPLC

Product Introduction

WIN 18446 AI Summary

WIN 18446 shows significant inhibitory activity on several aldehyde dehydrogenase isoforms. It inhibits human ALDH1A1, ALDH1A2, and ALDH1A3 with Ki values of 285.0 nM, 56.0 nM, and 261.0 nM, respectively. The compound also exhibits bioactivity, acting as an inhibitor of human ALDH1A1 with an IC50 of 102.0 nM and ALDH1A3 with an IC50 of 187.0 nM, when analyzed via LC-MS/MS in the presence of NAD+. Additionally, it exerts inhibitory effects on RALDH2 in living intact choroid isolated from 4-day recovering chick eyes, resulting in inhibition of ATRA synthesis. The inhibition percentages were 51.0%, 40.0%, and 76.0% at concentrations of 1 μM, 0.1 μM, and 10 μM, respectively, with an EC50 value of 44.47 nM. Lastly, WIN 18446 also inhibits N-terminal His6-tagged recombinant human mitochondrial ALDH2 using propionaldehyde as a substrate, with an IC50 value of 229.33 nM, further demonstrating its potent inhibitory activity..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

inhibitor of aldehyde dehydrogenase 1a2 (ALDH1a2)

Chemical Properties

Molecular Weight	366.11
Formula	C₁₂H₂₀Cl₄N₂O₂
Cas No.	1477-57-2
Smiles	ClC(Cl)C(=O)NCCCCCCCCNC(=O)C(Cl)Cl
Relative Density.	1.285g/cm3

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 45 mg/mL (122.91 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.46 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7314 mL	13.6571 mL	27.3142 mL	136.5710 mL
5 mM	0.5463 mL	2.7314 mL	5.4628 mL	27.3142 mL
10 mM	0.2731 mL	1.3657 mL	2.7314 mL	13.6571 mL
20 mM	0.1366 mL	0.6829 mL	1.3657 mL	6.8285 mL
50 mM	0.0546 mL	0.2731 mL	0.5463 mL	2.7314 mL
100 mM	0.0273 mL	0.1366 mL	0.2731 mL	1.3657 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc