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Anti-CD30/TNFRSF8 Antibody-APC (9U146) is a APC-conjugated Rabbit antibody targeting CD30/TNFRSF8. Anti-CD30/TNFRSF8 Antibody-APC (9U146) can be used in FCM.
Description | Anti-CD30/TNFRSF8 Antibody-APC (9U146) is a APC-conjugated Rabbit antibody targeting CD30/TNFRSF8. Anti-CD30/TNFRSF8 Antibody-APC (9U146) can be used in FCM. |
Ig Type | Monoclonal Rabbit IgG |
Clone | 9U146 |
Reactivity | Human |
Verified Activity | Flow cytometric analysis of Human TNFRSF8(CD30) expression on K562 cells. Cells were stained with APC-conjugated anti-Human TNFRSF8(CD30). The histogram were derived from gated events with the forward and side light-scatter characteristics of intact cells. |
Application | FCM |
Recommended Dose | 10 μl/Test, 0.1 mg/ml |
Antibody Type | Monoclonal |
Host Species | Rabbit |
Construction | This antibody was obtained from a rabbit immunized with purified, recombinant Human CD30 / TNFRSF8 (rh CD30 / TNFRSF8; TMPY-01827; NP_001234.2; Met1-Lys379) and conjugated with APC under optimum conditions, the unreacted APC was removed. |
Purification | Protein A |
Appearance | Liquid |
Formulation | PBS solution containing 0.5% BSA and 0.09% sodium azide |
Research Background | CD30, also known as TNFRSF8, is a cell membrane protein of the tumor necrosis factor receptor (TNFR) superfamily. CD30 protein is expressed by activated, but not resting, T and B cells. CD30 can regulate proliferation of lymphocytes and may also play an important role in human immunodeficiency virus replication. As a regulator of apoptosis, CD30 protein induces cell death or proliferation, depending on the cell type, and has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity. CD30 protein expression is upregulated in various hematological malignancies, including Reed-Sternberg cells in Hodgkin's disease (HD), anaplastic large cell lymphoma (ALCL) and subsets of Non-Hodgkin's lymphomas (NHLs), and CD30 is also linked to leukocytes in patients with chronic inflammatory diseases, including lupus erythematosus, asthma, rheumatoid arthritis and atopic dermatitis (AD).Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy |
Conjucates | APC |
Others Formats | PE |
Antibody Types Available | 2 |
Immunogen | Recombinant Human CD30 / TNFRSF8 protein (TMPY-01827) |
Antigen Species | Human |
Biology Area | Cancer Drug Targets |
Stability & Storage | Store at 2°C-8°C for 12 months, do not freeze. Keep away from direct sunlight. Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal. |
Transport | Shipping with blue ice. |
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