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TASIN-1

Name: TASIN-1
Brand: TargetMol
SKU: T22632
Price: 33 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T22632Cas No. 792927-06-1

Alias 1-[(4-methoxyphenyl)sulfonyl]-4'-methyl-4,1'-bipiperidine

TASIN-1 is a small molecule inhibitor of mutant adenomatous polyposis coli (APC).

TASIN-1

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Purity: 99.86%

Catalog No. T22632Alias 1-[(4-methoxyphenyl)sulfonyl]-4'-methyl-4,1'-bipiperidineCas No. 792927-06-1

TASIN-1 is a small molecule inhibitor of mutant adenomatous polyposis coli (APC).

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$33	In Stock	In Stock
5 mg	$76	In Stock	In Stock
10 mg	$133	In Stock	In Stock
25 mg	$283	In Stock	In Stock
50 mg	$455	In Stock	In Stock
100 mg	$672	In Stock	In Stock
500 mg	$1,430	Inquiry	Inquiry
1 mL x 10 mM (in DMSO)	$84	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.86%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	TASIN-1 is a small molecule inhibitor of mutant adenomatous polyposis coli (APC).
Targets&IC50	APC:50 μM(HCT116 cells), APC:70 nM(DLD1 cells)
In vitro	In two authentic human CRC cell lines HCT116 (WT APC) and DLD1 (truncated APC1417), TASIN-1 exhibited potent and selective toxicity toward DLD1 cells (IC50: 70 nM but not toward HCT116 cells (IC50 >50 μM)). TASIN-1 also reduced the endogenous cholesterol biosynthesis rate. TASIN-1 exerted its killing effects primarily by depleting cholesterol through inhibition of emopamil-binding protein (EBP) activity. However, knockdown of truncated APC (>90%) expression desensitized DLD1 cells to TASIN-1, suggesting that APC is required for TASIN-1’s cytotoxicity [1].
In vivo	In nude mice with established DLD1 and HT29 tumors, intraperitoneal injection of TASIN-1 twice daily for 18 days reduced the size of tumor xenografts and tumor growth rates. TASIN-1 resulted in the appearance of apoptotic cells with fragmented nuclei and induced an increase in cleaved caspase 3 and cleaved PARP1. However, TASIN-1 did not inhibit tumor growth in HCT116 xenografts. In a genetically engineered CRC mouse model, TASIN-1 significantly reduced tumor formation in the colons of CPC [1].
Synonyms	1-[(4-methoxyphenyl)sulfonyl]-4'-methyl-4,1'-bipiperidine

Chemical Properties

Molecular Weight	352.49
Formula	C₁₈H₂₈N₂O₃S
Cas No.	792927-06-1
Smiles	COc1ccc(cc1)S(=O)(=O)N1CCC(CC1)N1CCC(C)CC1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (156.03 mM), Sonication is recommended.

Ethanol: 12.02 mg/mL (34.1 mM), Sonication is recommended.

H2O: 2.45 mg/mL (6.95 mM), Sonication is recommended.

Solution Preparation Table

H2O/Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8370 mL	14.1848 mL	28.3696 mL	141.8480 mL
5 mM	0.5674 mL	2.8370 mL	5.6739 mL	28.3696 mL

Ethanol/DMSO

	1mg	5mg	10mg	50mg
10 mM	0.2837 mL	1.4185 mL	2.8370 mL	14.1848 mL
20 mM	0.1418 mL	0.7092 mL	1.4185 mL	7.0924 mL

DMSO

	1mg	5mg	10mg	50mg
50 mM	0.0567 mL	0.2837 mL	0.5674 mL	2.8370 mL
100 mM	0.0284 mL	0.1418 mL	0.2837 mL	1.4185 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc