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Torsemide

Name: Torsemide
Brand: TargetMol
SKU: T1410
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T1410Cas No. 56211-40-6

Alias Torasemide, JDL-464, AC-4464

Torsemide (AC-4464) is an anilinopyridine sulfonylurea belonging to the class of loop diuretics. Torsemide has a prolonged duration of action compared to other loop diuretics, is extensively protein bound in plasma and has a relatively long half-life.

Torsemide

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Purity: 99.81%

Catalog No. T1410Alias Torasemide, JDL-464, AC-4464Cas No. 56211-40-6

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$30	In Stock	In Stock
50 mg	$41	In Stock	In Stock
100 mg	$58	In Stock	In Stock
500 mg	$138	In Stock	In Stock
1 g	$198	-	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Purity:99.81%

Appearance:Solid

Color:White

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	Torsemide (AC-4464) is an anilinopyridine sulfonylurea belonging to the class of loop diuretics. Torsemide has a prolonged duration of action compared to other loop diuretics, is extensively protein bound in plasma and has a relatively long half-life.
In vitro	In rats, compared to baseline levels, Torsemide increases blood urea nitrogen (BUN) and plasma creatinine concentrations, and significantly and rapidly augments urine output. In canines with mitral valve closure, Torsemide elevates circulating angiotensin II and aldosterone levels, whereas furosemide only increases the level of angiotensin II.
In vivo	The primary action site of Torsemide is the thick ascending limb of the loop of Henle, where it promotes the excretion of water, sodium, and chloride by interacting with the K+, Na+, Cl- transporter. Torsemide disrupts the binding and secretion of aldosterone in a dose-dependent manner. It inhibits aldosterone secretion, which is produced by adrenal cortical cells of mice, guinea pigs, and cattle, and is stimulated in vivo by angiotensin, adrenocorticotropic hormone, butyryl cyclic AMP, corticosterone, or in vitro.
Synonyms	Torasemide, JDL-464, AC-4464

Chemical Properties

Molecular Weight	348.42
Formula	C₁₆H₂₀N₄O₃S
Cas No.	56211-40-6
Smiles	CC(C)NC(=O)NS(=O)(=O)C1=C(NC2=CC=CC(C)=C2)C=CN=C1
Relative Density.	1.283 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 22.5 mg/mL (64.58 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (2.87 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8701 mL	14.3505 mL	28.7010 mL	143.5050 mL
5 mM	0.5740 mL	2.8701 mL	5.7402 mL	28.7010 mL
10 mM	0.2870 mL	1.4350 mL	2.8701 mL	14.3505 mL
20 mM	0.1435 mL	0.7175 mL	1.4350 mL	7.1752 mL
50 mM	0.0574 mL	0.2870 mL	0.5740 mL	2.8701 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc