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KF38789

Name: KF38789
Brand: TargetMol
SKU: T22889
Price: 53 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T22889Cas No. 257292-29-8

Alias KF 38789

KF38789 is a selective inhibitor of P-selectin-mediated cell adhesion and P-selectin immunoglobulin G chimeric protein (IgG).

KF38789

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Purity: 99.81%

Catalog No. T22889Alias KF 38789Cas No. 257292-29-8

KF38789 is a selective inhibitor of P-selectin-mediated cell adhesion and P-selectin immunoglobulin G chimeric protein (IgG).

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$53	In Stock	In Stock
5 mg	$123	In Stock	In Stock
10 mg	$197	In Stock	In Stock
25 mg	$376	In Stock	In Stock
50 mg	$559	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.81%

Appearance:Solid

Color:Yellow

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	KF38789 is a selective inhibitor of P-selectin-mediated cell adhesion and P-selectin immunoglobulin G chimeric protein (IgG).
Targets&IC50	P-selectin-Ig:1.97 microM
In vitro	KF 38789, inhibited the binding of U937 cells to immobilized P-selectin immunoglobulin G chimeric protein (P-selectin-Ig) with an IC50 value of 1.97 microM. Cell adhesion to both E-selectin-Ig and L-selectin-Ig were not affected even by 100 microM of KF 38789. Moreover, KF 38789 inhibited P-selectin-induced superoxide production from human polymorphonuclear cells. Intravenously injected KF 38789 significantly inhibited the TG-induced accumulation of leukocytes in the mouse peritoneal cavity (p<0.01)[1].
In vivo	KF 38789 significantly reduced mechanical allodynia in the facial carrageenan-injected mice[2].
Synonyms	KF 38789

Chemical Properties

Molecular Weight	375.44
Formula	C₁₉H₂₁NO₅S
Cas No.	257292-29-8
Smiles	COc1ccc(C2CC(=NCCS2)C2C(O)OC(C)=CC2=O)c(OC)c1
Relative Density.	1.265g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 11.25 mg/mL (29.96 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6635 mL	13.3177 mL	26.6354 mL	133.1771 mL
5 mM	0.5327 mL	2.6635 mL	5.3271 mL	26.6354 mL
10 mM	0.2664 mL	1.3318 mL	2.6635 mL	13.3177 mL
20 mM	0.1332 mL	0.6659 mL	1.3318 mL	6.6589 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc