Anti-IFNAR1 Polyclonal Antibody

Name: Anti-IFNAR1 Polyclonal Antibody
Brand: TargetMol
SKU: TMAB-00913
Rating: 4.5 (1 reviews)

(Synonyms: interferon (α, β and Ω) receptor 1, interferon (alpha, beta and omega) receptor 1) Copy Product Info

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Synonyms: interferon (α, β and Ω) receptor 1, interferon (alpha, beta and omega) receptor 1

Catalog No. TMAB-00913 Copy Product Info

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Anti-IFNAR1 Polyclonal Antibody is a Rabbit antibody targeting IFNAR1. Anti-IFNAR1 Polyclonal Antibody can be used in FCM, ICC/IF, IF, IHC-Fr, IHC-P, WB.

Anti-IFNAR1 Polyclonal Antibody

Pack Size	Price	USA Stock	Global Stock
50 μL	$221	7-10 days	7-10 days
100 μL	$372	7-10 days	7-10 days
200 μL	$527	7-10 days	7-10 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Product Introduction

Bioactivity

Description	Anti-IFNAR1 Polyclonal Antibody is a Rabbit antibody targeting IFNAR1. Anti-IFNAR1 Polyclonal Antibody can be used in FCM, ICC/IF, IF, IHC-Fr, IHC-P, WB.
Synonyms	interferon (α, β and Ω) receptor 1, interferon (alpha, beta and omega) receptor 1
Ig Type	IgG
Reactivity	Human,Mouse,Rat (predicted:Cow,Sheep)

Application	FCM ICC/IF IF IHC-Fr IHC-P WB
Recommended Dose	FCM=1 μg/Test; ICC/IF=1:50-200; IF=1:100-500; IHC-Fr=1:100-500; IHC-P=1:100-500; WB=1:500-2000
Antibody Type	Polyclonal
Host Species	Rabbit
Subcellular Localization	Membrane.
Tissue Specificity	IFN receptors are present in all tissues and even on the surface of most IFN-resistant cells. Isoform 1, isoform 2 and isoform 3 are expressed in the IFN-alpha sensitive myeloma cell line U266S. Isoform 2 and isoform 3 are expressed in the IFN-alpha resis
Construction	Polyclonal Antibody
Purification	Protein A purified
Appearance	Liquid
Formulation	0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Concentration	1 mg/mL
Research Background	IFNAR1 is a member of the cytokine receptor superfamily which also includes receptors for interleukins, IFN gamma, ciliary neurotrophic factor, somatotrophin, erythropoietin, nerve growth factor, tumor necrosis factor, leukemia inhibitory factor, and oncostatin M. Some members of the family have an alpha chain with either low or high ligand binding affinity and at least one beta chain involved in signal transduction with either relatively low or no ligand binding affinity. Type I interferons, alpha and beta, induce a variety of effects on target cells including antiviral, antiproliferative, and immunomodulatory activities. The alpha and beta interferons compete to bind to a common cell surface receptor, while IFN gamma binds to a distinct receptor. IFNAR1 is very responsive to type I interferons and bind to IFN beta and IFN alpha subtypes. It is also functionally involved in signal transduction because of its association with the cytoplasmic tyrosine kinase JAK1. The type I interferons, alpha and beta, are produced by leukocytes (alpha subunits), fibroblasts (beta subtypes), lymphocytes (omega subtypes), and ruminant embryos (tau subtypes). Interferon receptors are generally found on most human cell types whatever their origin, even on cells poorly responsive to interferon. IFNAR1 is expressed on the cell surface in a variety of human cell lines.

Antigen Details

Immunogen	KLH conjugated synthetic peptide: human IFNAR1
Antigen Species	Human
Gene Name	IFNAR1
Gene ID	3454
Protein Name	Interferon alpha/beta receptor 1
Uniprot ID	P17181
Biology Area	Interferons,STATs,Interferons,STATs
Function	Associates with IFNAR2 to form the type I interferon receptor. Receptor for interferons alpha and beta. Binding to type I IFNs triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and IFNR alpha- and beta-subunits themselves.