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Y-33075

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Catalog No. T13384Cas No. 199433-58-4
Alias Y-39983 free base, Y39983 free base, Y33075

Y-33075 (Y-39983 free base) is a ROCK inhibitor that lowers intraocular pressure (IOP), increases blood flow to the optic nerve head (ONH), and increases the number of RGCs (retinal ganglion cells) in the body with regenerating axons.

Y-33075

Y-33075

😃Good
Catalog No. T13384Alias Y-39983 free base, Y39983 free base, Y33075Cas No. 199433-58-4
Y-33075 (Y-39983 free base) is a ROCK inhibitor that lowers intraocular pressure (IOP), increases blood flow to the optic nerve head (ONH), and increases the number of RGCs (retinal ganglion cells) in the body with regenerating axons.
Pack SizePriceAvailabilityQuantity
2 mg$112 In Stock
25 mg$766 6-8 weeks
50 mg$995 6-8 weeks
100 mg$1,630 6-8 weeks
1 mL x 10 mM (in DMSO)$329 5 days
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Product Introduction

Bioactivity
Description
Y-33075 (Y-39983 free base) is a ROCK inhibitor that lowers intraocular pressure (IOP), increases blood flow to the optic nerve head (ONH), and increases the number of RGCs (retinal ganglion cells) in the body with regenerating axons.
In vitro
The in vitro activity of Y-33075 was evaluated in cultured human umbilical vein endothelial cells (HUVECs). After seeding, HUVECs were treated with medium containing Y-33075 (1 μM) for 15 or 30 minutes. The cells exhibited contraction after treatment, but their morphology recovered within 1 hour after the removal of Y-33075. These results indicate that Y-33075 induces endothelial cell contraction, suggesting a potential effect on vascular barrier function [1].
In vivo
In rabbits, a single 50 μL dose of Y-33075 (0.003%–0.1%) reduced IOP by up to 13.2 ± 0.6 mmHg (0.1%, 2 h), and repeated dosing (0.03%, 4×/day for 28 days) maintained a 7.0–9.6 mmHg reduction. In monkeys, 0.05% Y-33075 reduced IOP by 2.5 ± 0.8 mmHg at 3 h. Y-33075 also enhanced conventional outflow in rabbits (+65.5%), with minimal side effects except occasional subconjunctival hemorrhage at high dosing frequency [2].
AliasY-39983 free base, Y39983 free base, Y33075
Chemical Properties
Molecular Weight280.32
FormulaC16H16N4O
Cas No.199433-58-4
SmilesN(C(=O)C1=CC=C([C@@H](C)N)C=C1)C2=C3C(NC=C3)=NC=C2
Relative Density.1.32 g/cm3
Storage & Solubility Information
Storagekeep away from direct sunlight,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
H2O: < 1 mg/mL (insoluble), Sonication is recommended.
DMSO: 40 mg/mL (142.69 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.5674 mL17.8368 mL35.6735 mL178.3676 mL
5 mM0.7135 mL3.5674 mL7.1347 mL35.6735 mL
10 mM0.3567 mL1.7837 mL3.5674 mL17.8368 mL
20 mM0.1784 mL0.8918 mL1.7837 mL8.9184 mL
50 mM0.0713 mL0.3567 mL0.7135 mL3.5674 mL
100 mM0.0357 mL0.1784 mL0.3567 mL1.7837 mL

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