Shopping Cart

Your shopping cart is currently empty

Y-33075

Name: Y-33075
Brand: TargetMol
SKU: T13384
Price: 112 USD
Availability: InStock
Rating: 5 (10 reviews)

Copy Product Info

😃Good

Catalog No. T13384Cas No. 199433-58-4

Alias Y-39983 free base, Y39983 free base, Y33075

Y-33075 (Y-39983 free base) is a ROCK inhibitor that lowers intraocular pressure (IOP), increases blood flow to the optic nerve head (ONH), and increases the number of RGCs (retinal ganglion cells) in the body with regenerating axons.

Y-33075

Copy Product Info

😃Good

Catalog No. T13384Alias Y-39983 free base, Y39983 free base, Y33075Cas No. 199433-58-4

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$112	-	In Stock
25 mg	$766	6-8 weeks	6-8 weeks
50 mg	$995	6-8 weeks	6-8 weeks
100 mg	$1,630	6-8 weeks	6-8 weeks
1 mL x 10 mM (in DMSO)	$329	5 days	5 days

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Appearance:Solid

Color:White

Resource Download

COA

Product Introduction

Bioactivity

Description	Y-33075 (Y-39983 free base) is a ROCK inhibitor that lowers intraocular pressure (IOP), increases blood flow to the optic nerve head (ONH), and increases the number of RGCs (retinal ganglion cells) in the body with regenerating axons.
In vitro	The in vitro activity of Y-33075 was evaluated in cultured human umbilical vein endothelial cells (HUVECs). After seeding, HUVECs were treated with medium containing Y-33075 (1 μM) for 15 or 30 minutes. The cells exhibited contraction after treatment, but their morphology recovered within 1 hour after the removal of Y-33075. These results indicate that Y-33075 induces endothelial cell contraction, suggesting a potential effect on vascular barrier function [1].
In vivo	In rabbits, a single 50 μL dose of Y-33075 (0.003%–0.1%) reduced IOP by up to 13.2 ± 0.6 mmHg (0.1%, 2 h), and repeated dosing (0.03%, 4×/day for 28 days) maintained a 7.0–9.6 mmHg reduction. In monkeys, 0.05% Y-33075 reduced IOP by 2.5 ± 0.8 mmHg at 3 h. Y-33075 also enhanced conventional outflow in rabbits (+65.5%), with minimal side effects except occasional subconjunctival hemorrhage at high dosing frequency [2].
Synonyms	Y-39983 free base, Y39983 free base, Y33075

Chemical Properties

Molecular Weight	280.32
Formula	C₁₆H₁₆N₄O
Cas No.	199433-58-4
Smiles	N(C(=O)C1=CC=C([C@@H](C)N)C=C1)C2=C3C(NC=C3)=NC=C2
Relative Density.	1.32 g/cm3

Storage & Solubility Information

Storage

keep away from direct sunlight,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: < 1 mg/mL (insoluble), Sonication is recommended.

DMSO: 40 mg/mL (142.69 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (7.13 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.5674 mL	17.8368 mL	35.6735 mL	178.3676 mL
5 mM	0.7135 mL	3.5674 mL	7.1347 mL	35.6735 mL
10 mM	0.3567 mL	1.7837 mL	3.5674 mL	17.8368 mL
20 mM	0.1784 mL	0.8918 mL	1.7837 mL	8.9184 mL
50 mM	0.0713 mL	0.3567 mL	0.7135 mL	3.5674 mL
100 mM	0.0357 mL	0.1784 mL	0.3567 mL	1.7837 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc