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DVD-445

Name: DVD-445
Brand: TargetMol
SKU: T11130
Price: 249 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T11130Cas No. 2375846-41-4

Alias DVD445, DVD 445

DVD-445 is an effective and covalent thioredoxin reductase 1 (TrxR1) inhibitor with an IC50 of 0.60 μM. DVD-445 is a peptidomimetic compound synthesised via the Ugi reaction, featuring an electrophilic moiety and demonstrating promising anticancer potential.

DVD-445

🥰Excellent

Catalog No. T11130Alias DVD445, DVD 445Cas No. 2375846-41-4

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$69	-	In Stock
5 mg	Preferential	-	In Stock
1 mL x 10 mM (in DMSO)	$249	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	DVD-445 is an effective and covalent thioredoxin reductase 1 (TrxR1) inhibitor with an IC50 of 0.60 μM. DVD-445 is a peptidomimetic compound synthesised via the Ugi reaction, featuring an electrophilic moiety and demonstrating promising anticancer potential.
Targets&IC50	TrxR1 (rat):0.60 μM
In vitro	DVD-445 exhibits cytotoxic effects on SH-SY5Y cells, U87 cells, HaCaT cells, and peripheral blood mononuclear cells (PBMCs), with IC₅₀ values of 10.99 μM, 9.70 μM, 8.30 μM, and 55.71 μM, respectively [1].
Synonyms	DVD445, DVD 445

Chemical Properties

Molecular Weight	458.5
Formula	C₂₅H₂₈F₂N₂O₄
Cas No.	2375846-41-4
Smiles	C(N(CCOC(/C=C/C(=O)C1=CC=C(F)C=C1)=O)C)(C(NC(C)(C)C)=O)C2=CC=C(F)C=C2
Relative Density.	no data available
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (174.48 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1810 mL	10.9051 mL	21.8103 mL	109.0513 mL
5 mM	0.4362 mL	2.1810 mL	4.3621 mL	21.8103 mL
10 mM	0.2181 mL	1.0905 mL	2.1810 mL	10.9051 mL
20 mM	0.1091 mL	0.5453 mL	1.0905 mL	5.4526 mL
50 mM	0.0436 mL	0.2181 mL	0.4362 mL	2.1810 mL
100 mM	0.0218 mL	0.1091 mL	0.2181 mL	1.0905 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

rat TrxR1DVD-445