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DVD-445

Name: DVD-445
Brand: TargetMol
SKU: T11130
Price: 249 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T11130Cas No. 2375846-41-4

Alias DVD445, DVD 445

DVD-445 is an effective and covalent thioredoxin reductase 1 (TrxR1) inhibitor with an IC50 of 0.60 μM. DVD-445 is a peptidomimetic compound synthesised via the Ugi reaction, featuring an electrophilic moiety and demonstrating promising anticancer potential.

DVD-445

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Catalog No. T11130Alias DVD445, DVD 445Cas No. 2375846-41-4

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$69	-	In Stock
5 mg	Preferential	-	In Stock
1 mL x 10 mM (in DMSO)	$249	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Appearance:Solid

Color:White

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COA

Product Introduction

Bioactivity

Description	DVD-445 is an effective and covalent thioredoxin reductase 1 (TrxR1) inhibitor with an IC50 of 0.60 μM. DVD-445 is a peptidomimetic compound synthesised via the Ugi reaction, featuring an electrophilic moiety and demonstrating promising anticancer potential.
Targets&IC50	TrxR1 (rat):0.60 μM
In vitro	DVD-445 exhibits cytotoxic effects on SH-SY5Y cells, U87 cells, HaCaT cells, and peripheral blood mononuclear cells (PBMCs), with IC₅₀ values of 10.99 μM, 9.70 μM, 8.30 μM, and 55.71 μM, respectively [1].
Synonyms	DVD445, DVD 445

Chemical Properties

Molecular Weight	458.5
Formula	C₂₅H₂₈F₂N₂O₄
Cas No.	2375846-41-4
Smiles	C(N(CCOC(/C=C/C(=O)C1=CC=C(F)C=C1)=O)C)(C(NC(C)(C)C)=O)C2=CC=C(F)C=C2
Relative Density.	no data available

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (174.48 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1810 mL	10.9051 mL	21.8103 mL	109.0513 mL
5 mM	0.4362 mL	2.1810 mL	4.3621 mL	21.8103 mL
10 mM	0.2181 mL	1.0905 mL	2.1810 mL	10.9051 mL
20 mM	0.1091 mL	0.5453 mL	1.0905 mL	5.4526 mL
50 mM	0.0436 mL	0.2181 mL	0.4362 mL	2.1810 mL
100 mM	0.0218 mL	0.1091 mL	0.2181 mL	1.0905 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

rat TrxR1DVD-445