Immobilized Human AXL, His Tag at 1 μg/ml (100 μl/well) on the plate. Dose response curve for Anti-AXL Antibody, hFc Tag with the EC50 of 10.0 ng/ml determined by ELISA.

AXL Protein, Human, Recombinant (aa 33-442, His) is expressed in HEK293 Cells. The accession number is NP_068713.2.

Human

HEK293 Cells

UFO,Tyro7,JTK11,AXL receptor tyrosine kinase,ARK

Glu33-Ser442

> 95% as determined by Tris-Bis PAGE; > 95% as determined by HPLC

Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

Axl, a member of the TAM (Tyro3, Axl, Mer) family, and its inhibitors can specifically break the kinase signaling nodes, allowing advanced patients to regain drug sensitivity with improved therapeutic efficacy. Overexpression and activation of Axl receptor tyrosine kinase have been widely accepted to promote cell proliferation, chemotherapy resistance, invasion, and metastasis in several human cancers, such as lung, breast, and pancreatic cancers.