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Isosorbide dinitrate

Name: Isosorbide dinitrate
Brand: TargetMol
SKU: T1479
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T1479Cas No. 87-33-2

Alias Sorbidnitrate, Sorbide nitrate, Nitrosorbide, Isordil

Isosorbide dinitrate (Isordil) is a vasodilator used in the treatment of angina pectoris.

Isosorbide dinitrate

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Purity: 99.87%

Catalog No. T1479Alias Sorbidnitrate, Sorbide nitrate, Nitrosorbide, IsordilCas No. 87-33-2

Isosorbide dinitrate (Isordil) is a vasodilator used in the treatment of angina pectoris.

Pack Size	Price	USA Warehouse	Global Warehouse
10 mg	$37	In Stock	In Stock
25 mg	$76	In Stock	In Stock
50 mg	$126	In Stock	In Stock
100 mg	$197	In Stock	In Stock
500 mg	$455	Inquiry	Inquiry
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:99.87%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Isosorbide dinitrate AI Summary

Isosorbide dinitrate exhibits a diverse range of bioactivities, including nitric oxide release and cell cytotoxicity. It shows varying levels of nitric oxide release under different conditions and times, indicating its potential for modulating NO levels. The compound demonstrates cytotoxic effects against various cell lines, with CC50 values indicating its potency in inhibiting cell proliferation. Cardiovascular effects are also notable, with a significant reduction in T-wave increase of rat EKG and arterial blood pressure in rabbits. It acts as a vasodilator in multiple models, including rat aorta and pig pulmonary artery, with EC50 values illustrating its potency. In pharmacokinetic studies, Isosorbide dinitrate displays species-specific properties, such as a low volume of distribution and high clearance rates in humans and monkeys. The compound exhibits antiviral activities, specifically inhibiting SARS-CoV-2 induced cytotoxicity and the 3CL-Pro protease. It also inhibits HDAC6 activity and shows drug metabolism activity with nitric oxide release in phosphate buffer. Despite these bioactivities, Isosorbide dinitrate shows minimal potential for drug-induced liver injury and presents moderate hepatotoxicity. The compound's permeability coefficient in human skin and its low inhibition activity against SARS-CoV-2 in Vero E6 cells highlight its varied pharmacological profile..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Isosorbide dinitrate (Isordil) is a vasodilator used in the treatment of angina pectoris.
Synonyms	Sorbidnitrate, Sorbide nitrate, Nitrosorbide, Isordil

Chemical Properties

Molecular Weight	236.14
Formula	C₆H₈N₂O₈
Cas No.	87-33-2
Smiles	[O-][N+](=O)O[C@@H]1CO[C@@H]2[C@H](CO[C@H]12)O[N+]([O-])=O
Relative Density.	1.7503 g/cm3 (Estimated)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 245 mg/mL (1037.52 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (8.47 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.2348 mL	21.1739 mL	42.3478 mL	211.7388 mL
5 mM	0.8470 mL	4.2348 mL	8.4696 mL	42.3478 mL
10 mM	0.4235 mL	2.1174 mL	4.2348 mL	21.1739 mL
20 mM	0.2117 mL	1.0587 mL	2.1174 mL	10.5869 mL
50 mM	0.0847 mL	0.4235 mL	0.8470 mL	4.2348 mL
100 mM	0.0423 mL	0.2117 mL	0.4235 mL	2.1174 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc