TCN2 Protein, Human, Recombinant (His)

Name: TCN2 Protein, Human, Recombinant (His)
Brand: TargetMol
SKU: TMPY-01003
Price: 109 USD
Availability: InStock
Rating: 5 (10 reviews)

(Synonyms: transcobalamin II, TCII, TC-2, TC2, TC, II, D22S750, D22S676) Copy Product Info

Synonyms: transcobalamin II, TCII, TC-2, TC2, TC, II, D22S750, D22S676

Catalog No. TMPY-01003 Copy Product Info

TCN2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 46.7 kDa and the accession number is P20062-1.

Pack Size	Price	USA Stock	Global Stock
5 µg	$109	-	In Stock
10 µg	$182	-	In Stock
20 µg	$296	-	In Stock
50 µg	$600	-	In Stock
100 µg	$1,030	7-10 days	7-10 days
200 µg	$1,750	7-10 days	7-10 days
500 µg	$3,530	7-10 days	7-10 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:92.5%

Appearance:Lyophilized powder

Color:White

Resource Download

COA User Guide of Recombinant Proteins

Product Introduction

Bioactivity

Bioactivity	Immobilized CD320 Protein, Mouse, Recombinant (hFc Tag) at 2 μg/mL (100 μL/well) can bind TCN2 Protein, Human, Recombinant (His Tag), the EC50 is 10-62 ng/mL.
Description	TCN2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 46.7 kDa and the accession number is P20062-1.
Species	Human
Expression System	HEK293 Cells
Tag	C-His
Accession Number	P20062-1
Construction	A DNA sequence encoding the human TCN2 (NP_000346.2) (Met 1-Trp 427) with a C-terminal polyhistidine tag was expressed. Predicted N terminal: Glu 19
Protein Purity	> 90 % as determined by SDS-PAGE
Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Formulation	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
Reconstitution	Reconstituted with sterile deionized water to 0.25 mg/mL. Reconstitution conditions may vary depending on the lot.
Synonyms	transcobalamin II, TCII, TC-2, TC2, TC, II, D22S750, D22S676
Research Background	Transcobalamin II, also known as TCN2 and TC II, is a plasma protein that binds cobalamin (Cbl; vitamin B12) as it is absorbed in the terminal ileum and distributes to tissues. The circulating transcobalamin II-cobalamin complex binds to receptors on the plasma membrane of tissue cells and is then internalized by receptor-mediated endocytosis. Transcobalamin II is a non-glycolated secretory protein of molecular mass 43 kDa. Its plasma membrane receptor (TC II-R) is a heavily glycosylated protein with a monomeric molecular mass of 62 kDa. Human TCN2 gene is composed of nine exons and eight introns spanning approximately 2 kb with multiple potential transcription start sites. A number of genetic abnormalities are characterized either by a failure to express TCN2 or by synthesis of an abnormal protein. The TCN2 deficiency results in cellular cobalamin deficiency, an early onset of megaloblastic anaemia, and neurological abnormalities.

Chemical Properties

Molecular Weight

46.7 kDa (predicted); 43 kDa (reducing conditions)

Storage & Solubility Information

Shipping	In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.
Storage	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.