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Enoticumab (Synonyms: SAR-153192, SAR153192, REGN-421, REGN421)
Catalog No. T80615 Copy Product Info
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Enoticumab (REGN421) is a fully human IgG1 monoclonal antibody with anticancer activity that inhibits the growth of cancer cells.Enoticumab binds human Dll4 and disrupts Notch-mediated signaling.
Enoticumab
Copy Product Info🥰Excellent
Catalog No. T80615
Synonyms SAR-153192, SAR153192, REGN-421, REGN421
Enoticumab (REGN421) is a fully human IgG1 monoclonal antibody with anticancer activity that inhibits the growth of cancer cells.Enoticumab binds human Dll4 and disrupts Notch-mediated signaling.
Enoticumab
Cas No. 1192578-27-0
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| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 1 mg | $263 | - | In Stock | |
| 5 mg | $795 | - | In Stock | |
| 10 mg | $1,260 | - | In Stock | |
| 25 mg | $1,870 | - | In Stock | |
| 50 mg | $2,520 | - | In Stock |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.
For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:98.2% (SDS-PAGE); 98.9% (SEC-HPLC)
Appearance:Liquid
Color:Transparent
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| Description | Enoticumab (REGN421) is a fully human IgG1 monoclonal antibody with anticancer activity that inhibits the growth of cancer cells.Enoticumab binds human Dll4 and disrupts Notch-mediated signaling. |
| In vivo | In an ovarian xenograft model, Enoticumab demonstrates specific in vivo activity. EGN421 (2.5 mg/kg, administered once weekly) achieved tumor growth inhibition of 86% and 83% in subcutaneous TOV-112D and intraperitoneal A2780 human tumor xenograft models in mice, respectively. [1] |
| Synonyms | SAR-153192, SAR153192, REGN-421, REGN421 |
| Reactivity | Human |
| Verified Activity | Immobilized Human DLL4 Protein (His) (TMPY-01321) at 1 μg/mL (100 μL/well) can bind Enoticumab. The EC50 is 8.72 ng/mL.  |
| Application | Functional assay |
| Antibody Type | Monoclonal |
| Formulation | Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition. |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Gene ID | |
| Uniprot ID | |
| Target | DLL4 |
| Molecular Weight | 146.22 kDa |
| Cas No. | 1192578-27-0 |
| Isotype | Human IgG1 kappa |
| Recommended Isotype Control |
| Storage | -20°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
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