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Enoticumab (Synonyms: SAR-153192, SAR153192, REGN-421, REGN421)

Catalog No. T80615 Copy Product Info
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Enoticumab (REGN421) is a fully human IgG1 monoclonal antibody with anticancer activity that inhibits the growth of cancer cells.Enoticumab binds human Dll4 and disrupts Notch-mediated signaling.

Enoticumab

Copy Product Info
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Catalog No. T80615
Synonyms SAR-153192, SAR153192, REGN-421, REGN421

Enoticumab (REGN421) is a fully human IgG1 monoclonal antibody with anticancer activity that inhibits the growth of cancer cells.Enoticumab binds human Dll4 and disrupts Notch-mediated signaling.

Enoticumab
Cas No. 1192578-27-0
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Pack SizePriceUSA StockGlobal StockQuantity
1 mg$263-In Stock
5 mg$795-In Stock
10 mg$1,260-In Stock
25 mg$1,870-In Stock
50 mg$2,520-In Stock
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Batch Information

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Purity:98.2% (SDS-PAGE); 98.9% (SEC-HPLC)
Appearance:Liquid
Color:Transparent
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Product Introduction

Bioactivity
Description
Enoticumab (REGN421) is a fully human IgG1 monoclonal antibody with anticancer activity that inhibits the growth of cancer cells.Enoticumab binds human Dll4 and disrupts Notch-mediated signaling.
In vivo
In an ovarian xenograft model, Enoticumab demonstrates specific in vivo activity. EGN421 (2.5 mg/kg, administered once weekly) achieved tumor growth inhibition of 86% and 83% in subcutaneous TOV-112D and intraperitoneal A2780 human tumor xenograft models in mice, respectively. [1]
SynonymsSAR-153192, SAR153192, REGN-421, REGN421
Reactivity
Human
Application
Functional assay
Antibody Type
Monoclonal
FormulationSupplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition.
Endotoxin<1.0 EU/mg
Related Conjugates and Formulations
Conjucates
Unconjugated
Antigen Details
Gene ID
Uniprot ID
TargetDLL4
Chemical Properties
Molecular Weight146.22 kDa
Cas No.1192578-27-0
Antibody Information
IsotypeHuman IgG1 kappa
Recommended Isotype Control
Storage & Solubility Information
Storagestore at low temperature | -20°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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