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Enoticumab
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Catalog No. T80615Cas No. 1192578-27-0
Alias SAR-153192, SAR153192, REGN-421, REGN421
Enoticumab (REGN421) is a fully human IgG1 monoclonal antibody with anticancer activity that inhibits the growth of cancer cells.Enoticumab binds human Dll4 and disrupts Notch-mediated signaling.
Enoticumab
Enoticumab
😃Good
Catalog No. T80615Alias SAR-153192, SAR153192, REGN-421, REGN421Cas No. 1192578-27-0
Enoticumab (REGN421) is a fully human IgG1 monoclonal antibody with anticancer activity that inhibits the growth of cancer cells.Enoticumab binds human Dll4 and disrupts Notch-mediated signaling.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $263 | - | In Stock | |
| 5 mg | $795 | - | In Stock | |
| 10 mg | $1,260 | - | In Stock | |
| 25 mg | $1,870 | - | In Stock | |
| 50 mg | $2,520 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:98.2% (SDS-PAGE); 98.9% (SEC-HPLC)
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| Description | Enoticumab (REGN421) is a fully human IgG1 monoclonal antibody with anticancer activity that inhibits the growth of cancer cells.Enoticumab binds human Dll4 and disrupts Notch-mediated signaling. |
| In vivo | In an ovarian xenograft model, Enoticumab demonstrates specific in vivo activity. EGN421 (2.5 mg/kg, administered once weekly) achieved tumor growth inhibition of 86% and 83% in subcutaneous TOV-112D and intraperitoneal A2780 human tumor xenograft models in mice, respectively. [1] |
| Synonyms | SAR-153192, SAR153192, REGN-421, REGN421 |
| Reactivity | Human |
| Application | Functional assay |
| Antibody Type | Monoclonal |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Gene ID | |
| Uniprot ID | |
| Target | DLL4 |
| Molecular Weight | 146.22 kDa |
| Cas No. | 1192578-27-0 |
| Isotype | Human IgG1 kappa |
| Recommended Isotype Control |
| Storage | store at low temperature | -20°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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