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Steviol
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Catalog No. T2S1837Cas No. 471-80-7
Alias NSC 226902, Hydroxydehydrostevic acid
1. Steviol (NSC-226902), a natural sweetener, it inhibits proliferation of the gastrointestinal cancer cells intensively. 2. Steviol can induce a significant increase in CYP3A29 expression. 3. Steviol inhibits the proliferation of the human osteosarcoma U2OS cell line in a dose- and time-dependent manner. 4. Steviol can treat polycystic kidney disease, it slowed cyst growth, in part, by reducing AQP2 transcription, promoted proteasome, and lysosome-mediated AQP2 degradation.
Steviol
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Purity: 99.92%
Catalog No. T2S1837Alias NSC 226902, Hydroxydehydrostevic acidCas No. 471-80-7
1. Steviol (NSC-226902), a natural sweetener, it inhibits proliferation of the gastrointestinal cancer cells intensively. 2. Steviol can induce a significant increase in CYP3A29 expression. 3. Steviol inhibits the proliferation of the human osteosarcoma U2OS cell line in a dose- and time-dependent manner. 4. Steviol can treat polycystic kidney disease, it slowed cyst growth, in part, by reducing AQP2 transcription, promoted proteasome, and lysosome-mediated AQP2 degradation.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $44 | In Stock | In Stock | |
| 5 mg | $96 | In Stock | In Stock | |
| 10 mg | $165 | In Stock | In Stock | |
| 25 mg | $278 | In Stock | In Stock | |
| 50 mg | $413 | In Stock | In Stock | |
| 100 mg | $613 | - | In Stock | |
| 200 mg | $873 | - | In Stock | |
| 1 mL x 10 mM (in DMSO) | $70 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.92%
Color:White
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Product Introduction
Steviol AI Summary
Steviol shows a diverse range of biological activities. It functions as an inhibitor of HIV1 Reverse Transcriptase, with an IC50 value greater than 200.0 µg/mL. The compound also inhibits TPA-induced EBV-early antigen activation in human Raji cells and demonstrates cytotoxicity at multiple mol ratios. In mouse models, it reduces DMBA-induced/TPA-promoted skin papillomas and shows inhibitory effects on peroxynitrite-induced/TPA-promoted carcinogenesis in Sencar mice. Steviol acts as an agonist at the glucocorticoid receptor in mouse RAW264.7 cells, assessed by a dual luciferase reporter assay with a firefly/renilla luciferase ratio of 1.45 at 10 µM. It displays bioactivity as a potential inhibitor of mitochondrial division or activator of mitochondrial fusion with a potency of 20596.2 nM and as an inhibitor of Histone Lysine Methyltransferase G9a with a potency of 31622.8 nM. The compound exhibits antiviral activity against Hepatitis B virus in human HuH7 cells, inhibiting viral DNA replication and HBeAg secretion with IC50 values of 19900.0 nM and 16600.0-20800.0 nM, respectively, and a TC50 value of 474.5 µM. In terms of antiproliferative activity, it has an IC50 value of 185,000.0 nM in human MCF7 cells and shows IC50 values greater than 10,000 nM in various other human cell lines such as A549, HCT-116, HeLa, Huh-7, and MDA-MB-231..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | 1. Steviol (NSC-226902), a natural sweetener, it inhibits proliferation of the gastrointestinal cancer cells intensively. 2. Steviol can induce a significant increase in CYP3A29 expression. 3. Steviol inhibits the proliferation of the human osteosarcoma U2OS cell line in a dose- and time-dependent manner. 4. Steviol can treat polycystic kidney disease, it slowed cyst growth, in part, by reducing AQP2 transcription, promoted proteasome, and lysosome-mediated AQP2 degradation. |
| Synonyms | NSC 226902, Hydroxydehydrostevic acid |
| Molecular Weight | 318.45 |
| Formula | C20H30O3 |
| Cas No. | 471-80-7 |
| Smiles | C[C@]12CCC[C@](C)([C@@H]1CC[C@]13CC(=C)[C@@](O)(C1)CC[C@H]23)C(O)=O |
| Relative Density. | 1.17 g/cm3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 125 mg/mL (392.53 mM), Sonication is recommended.  | |||||||||||||||||||||||||||||||||||
| In Vivo Formulation | 10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (6.28 mM), Sonication is recommended. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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