Progranulin Protein, Mouse, Recombinant (His) V2

Name: Progranulin Protein, Mouse, Recombinant (His) V2
Brand: TargetMol
SKU: TMPY-01435U
Rating: 4.5 (1 reviews)

(Synonyms: Pgrn, Granulin Precursor, epithelin) Copy Product Info

Synonyms: Pgrn, Granulin Precursor, epithelin

Catalog No. TMPY-01435U Copy Product Info

Progranulin Protein, Mouse, Recombinant (His) V2 is expressed in HEK293 Cells. The accession number is P28798.

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Pack Size	Price	USA Stock	Global Stock
5 µg	$98	7-10 days	7-10 days
10 µg	$169	7-10 days	7-10 days
20 µg	$278	7-10 days	7-10 days
50 µg	$553	7-10 days	7-10 days
100 µg	$935	7-10 days	7-10 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Bioactivity

Bioactivity	Activity has not been tested. It is theoretically active, but we cannot guarantee it.
Description	Progranulin Protein, Mouse, Recombinant (His) V2 is expressed in HEK293 Cells. The accession number is P28798.
Species	Mouse
Expression System	HEK293 Cells
Tag	C-His
Accession Number	P28798
Construction	Thr18-Leu589
Protein Purity	> 95% as determined by Tris-Bis PAGE; > 95% as determined by HPLC
Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Formulation	Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution	Reconstitute the lyophilized protein in sterile deionized water. The product concentration should not be less than 100 μg/mL. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
Synonyms	Pgrn, Granulin Precursor, epithelin
Research Background	Haploinsufficiency of progranulin (PGRN) is a leading cause of frontotemporal lobar degeneration (FTLD). Loss of PGRN leads to lysosome dysfunction during aging. TMEM106B, a gene encoding a lysosomal membrane protein, is the main risk factor for FTLD with PGRN haploinsufficiency.Loss of both PGRN and TMEM106B results in an increased accumulation of lysosomal vacuoles in the axon initial segment of motor neurons and enhances the manifestation of FTLD phenotypes with a much earlier onset.

Chemical Properties

Molecular Weight

62.7 kDa (Predicted); 70-80 kDa (Due to glycosylation)

Storage & Solubility Information

Shipping	In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.
Storage	Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.