Progranulin Protein, Mouse, Recombinant (His) V2

Catalog No. TMPY-01435U

Progranulin Protein, Mouse, Recombinant (His) V2 is expressed in HEK293 Cells. The accession number is P28798.

Progranulin Protein, Mouse, Recombinant (His) V2

Catalog No. TMPY-01435U

Progranulin Protein, Mouse, Recombinant (His) V2 is expressed in HEK293 Cells. The accession number is P28798.

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Biological Activity	Activity has not been tested. It is theoretically active, but we cannot guarantee it.
Description	Progranulin Protein, Mouse, Recombinant (His) V2 is expressed in HEK293 Cells. The accession number is P28798.
Species	Mouse
Expression System	HEK293 Cells
Accession Number	P28798
Synonyms	Pgrn,Granulin Precursor,epithelin
Construction	Thr18-Leu589
Protein Purity	> 95% as determined by Tris-Bis PAGE; > 95% as determined by HPLC
Molecular Weight	62.7 kDa (Predicted); 70-80 kDa (Due to glycosylation)
Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Formulation	Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Stability & Storage	Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
Shipping	In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice.
Research Background	Haploinsufficiency of progranulin (PGRN) is a leading cause of frontotemporal lobar degeneration (FTLD). Loss of PGRN leads to lysosome dysfunction during aging. TMEM106B, a gene encoding a lysosomal membrane protein, is the main risk factor for FTLD with PGRN haploinsufficiency.Loss of both PGRN and TMEM106B results in an increased accumulation of lysosomal vacuoles in the axon initial segment of motor neurons and enhances the manifestation of FTLD phenotypes with a much earlier onset.