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Diclofenac Potassium

Name: Diclofenac Potassium
Brand: TargetMol
SKU: T6470
Price: 37 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T6470Cas No. 15307-81-0

Alias Voltfast, CGP-45840B, Cataflam

Diclofenac Potassium (CGP-45840B) is a nonsteroidal anti-inflammatory drug taken to reduce inflammation and as an analgesic reducing pain in certain conditions.

Diclofenac Potassium

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Purity: 99.51%

Catalog No. T6470Alias Voltfast, CGP-45840B, CataflamCas No. 15307-81-0

Diclofenac Potassium (CGP-45840B) is a nonsteroidal anti-inflammatory drug taken to reduce inflammation and as an analgesic reducing pain in certain conditions.

Pack Size	Price	USA Warehouse	Global Warehouse
500 mg	$40	In Stock	In Stock
1 g	$42	In Stock	In Stock
5 g	$48	-	In Stock
10 g	$71	-	In Stock
25 g	$117	-	In Stock
1 mL x 10 mM (in DMSO)	$37	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.51%

Appearance:Solid

Color:White

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	Diclofenac Potassium (CGP-45840B) is a nonsteroidal anti-inflammatory drug taken to reduce inflammation and as an analgesic reducing pain in certain conditions.
Targets&IC50	COX-1 (ovine):5.1 nM (IC50), COX-1 (ovine):0.84 nM (IC50), COX-2(human):1.3 nM (IC50, in CHO cells), COX-1 (human):4 nM (IC50, in CHO cells)
In vitro	The primary mechanism of diclofenac responsible for its anti-inflammatory, antipyretic, and analgesic action is thought to be inhibition of prostaglandin synthesis by inhibition of cyclooxygenase (COX). It also appears to exhibit bacteriostatic activity by inhibiting bacterial DNA synthesis. Inhibition of COX also decreases prostaglandins in the epithelium of the stomach, making it more sensitive to corrosion by gastric acid. This is also the main side effect of diclofenac. Diclofenac has a low to moderate preference to block the COX2-isoenzyme (approximately 10-fold) and is said to have, therefore, a somewhat lower incidence of gastrointestinal complaints than noted with indomethacin and aspirin.
Synonyms	Voltfast, CGP-45840B, Cataflam

Chemical Properties

Molecular Weight	334.24
Formula	C₁₄H₁₀Cl₂KNO₂
Cas No.	15307-81-0
Smiles	[K+].[O-]C(=O)CC1=CC=CC=C1NC1=C(Cl)C=CC=C1Cl
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 10 mg/mL (29.92 mM), Sonication is recommended.

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 55 mg/mL (164.55 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.98 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9919 mL	14.9593 mL	29.9186 mL	149.5931 mL
5 mM	0.5984 mL	2.9919 mL	5.9837 mL	29.9186 mL
10 mM	0.2992 mL	1.4959 mL	2.9919 mL	14.9593 mL
20 mM	0.1496 mL	0.7480 mL	1.4959 mL	7.4797 mL

DMSO

	1mg	5mg	10mg	50mg
50 mM	0.0598 mL	0.2992 mL	0.5984 mL	2.9919 mL
100 mM	0.0299 mL	0.1496 mL	0.2992 mL	1.4959 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc