Shopping Cart

Your shopping cart is currently empty

L-Glutamine

Name: L-Glutamine
Brand: TargetMol
SKU: T0326L
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

(Synonyms: L-Glutamic acid 5-amide) Copy Product Info

🥰Excellent

Synonyms: L-Glutamic acid 5-amide

Catalog No. T0326L Copy Product Info

Purity: 99.98%

🥰Excellent

L-Glutamine (L-Glutamic acid 5-amide) is a non-essential amino acid abundantly present in the human body and involved in numerous metabolic processes. It serves multiple functions as a nitrogen source donor, energy substrate, and antioxidant precursor. It can be used in cell biology, immunology, and oncology research.

Cas No. 56-85-9

Pack Size	Price	USA Stock	Global Stock	Quantity
5 g	$29	-	In Stock
1 mL x 10 mM (in H2O)	$50	In Stock	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

Add to Cart

Add to Quotation

For research use only—not for human use. No sales to individuals. Use as intended only.

Questions

Batch Information

Select Batch

Purity:99.98%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	L-Glutamine (L-Glutamic acid 5-amide) is a non-essential amino acid abundantly present in the human body and involved in numerous metabolic processes. It serves multiple functions as a nitrogen source donor, energy substrate, and antioxidant precursor. It can be used in cell biology, immunology, and oncology research.
Targets & IC50	mGluR7:19 μM
In vitro	Methods: L-glutamine (0.5, 1.0, 2.0, 10.0 mM) was added to male SD rat thoracic aortic vascular rings (with endothelium) (pre-contracted with 1 μM phenylephrine), and tension changes were recorded in real time. Results: 0.5 mM L-Glutamine increased relaxation velocity by 93%. De-endothelialization or L-NAME pretreatment attenuated the relaxation response by approximately 70–80%. L-Glutamine increased tissue cGMP levels by 77%. [1] Methods: Primary knee cartilage cells from 3-week-old SD rats were treated with L-glutamine (0, 5, 10, 20 mM). Some groups were pretreated with IL-1β (10 ng/mL) for 2 hours before L-glutamine treatment for 24 or 48 hours. Cell viability was assessed using the CCK-8 assay. Results: IL-1β reduced cell viability, while L-Glutamine concentration-dependently reversed this effect, with the most pronounced effect observed at 20 mM. [2]
In vivo	Methods: Female BALB/c mice received a single intraperitoneal injection of cantharidin (CTD) (2 mg/kg) or oral administration of L-glutamine (Gln) (1 or 2 g/kg). Four hours post-treatment, hearts were subjected to hematoxylin and eosin (HE) staining, and microscopic examination was performed to assess pathological changes such as inflammation and congestion. Results: The CTD group exhibited inflammatory cell infiltration and myocardial interstitial congestion in the heart; the L-Glutamine pretreatment group showed significantly reduced myocardial inflammation and pathological alterations. [3] Methods: Male C57BL/6J mice received intraperitoneal injections of L-glutamine (Gln) (50 mg/kg). Thirty minutes later, LPS (10 μg/kg) + D-Gal (700 mg/kg) was administered intraperitoneally to induce fulminant hepatitis. Animals were euthanized 6 hours after LPS/D-Gal injection.Plasma samples were collected to measure ALT and AST activity; liver tissue was examined histopathologically via HE staining. Results: L-Glutamine pretreatment significantly reduced LPS/D-Gal-induced elevations in plasma ALT and AST levels and mitigated histopathological liver damage (disorganized hepatic lobule architecture, hepatocyte necrosis, inflammatory cell infiltration).[4]
Synonyms	L-Glutamic acid 5-amide

Chemical Properties

Molecular Weight	146.14
Formula	C₅H₁₀N₂O₃
Cas No.	56-85-9
Smiles	[C@H](CCC(N)=O)(C(O)=O)N
Relative Density.	1.469 g/cm3. Temperature:20 °C.;1.469. Temperature:20 °C.

Storage & Solubility Information

Storage

Store at low temperature Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: Insoluble

H2O: 40.7 mg/mL (278.5 mM), Sonication and heating are recommended.

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	6.8428 mL	34.2138 mL	68.4275 mL	342.1377 mL
5 mM	1.3686 mL	6.8428 mL	13.6855 mL	68.4275 mL
10 mM	0.6843 mL	3.4214 mL	6.8428 mL	34.2138 mL
20 mM	0.3421 mL	1.7107 mL	3.4214 mL	17.1069 mL
50 mM	0.1369 mL	0.6843 mL	1.3686 mL	6.8428 mL
100 mM	0.0684 mL	0.3421 mL	0.6843 mL	3.4214 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.