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Anti-Beta Klotho Polyclonal Antibody (Alias: Klotho beta-like protein, KLB, BKL, Beta-klotho, BetaKlotho)
Catalog No. TMAB-00211 Copy Product Info
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Anti-Beta Klotho Polyclonal Antibody is a Rabbit antibody targeting Beta Klotho. Anti-Beta Klotho Polyclonal Antibody can be used in ELISA,ICC/IF,IF,IHC-Fr,IHC-P,WB.
Anti-Beta Klotho Polyclonal Antibody
Copy Product Info🥰Excellent
Catalog No. TMAB-00211
Alias Klotho beta-like protein, KLB, BKL, Beta-klotho, BetaKlotho
Anti-Beta Klotho Polyclonal Antibody is a Rabbit antibody targeting Beta Klotho. Anti-Beta Klotho Polyclonal Antibody can be used in ELISA,ICC/IF,IF,IHC-Fr,IHC-P,WB.
Anti-Beta Klotho Polyclonal Antibody
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 50 μL | $220 | 7-10 days | 7-10 days | |
| 100 μL | $373 | 7-10 days | 7-10 days | |
| 200 μL | $528 | 7-10 days | 7-10 days |
In stock · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Antigen Details
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| Description | Anti-Beta Klotho Polyclonal Antibody is a Rabbit antibody targeting Beta Klotho. Anti-Beta Klotho Polyclonal Antibody can be used in ELISA,ICC/IF,IF,IHC-Fr,IHC-P,WB. |
| Synonyms | Klotho beta-like protein, KLB, BKL, Beta-klotho, BetaKlotho |
| Ig Type | IgG |
| Reactivity | (predicted:Human,Mouse,Rat,Sheep) |
| Application | |
| Recommended Dose | WB: 1:500-2000; IHC-P: 1:100-500; IHC-Fr: 1:100-500; ICC/IF: 1:100-500; IF: 1:100-500; ELISA: 1:5000-10000 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Cell membrane. |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1 mg/mL |
| Research Background | BetaKlotho is a 1044 amino acid single-pass type III membrane protein that plays a key role in bile acid and cholesterol metabolism by suppressing transcription of CYP7A1 (cholesterol 7-alpha-hydroxylase), the rate-limiting enzyme in bile acid synthesis. Homozygous negative betaKlotho mice showed dramatically elevated bile acid synthesis and secretion, as well as a strong upregulation of CYP7A1 and CYP8B1 and resistance to gallstone formation. FGF19 and FGF21 require direct interaction with betaKlotho for activation, intracellular signaling and gene expression modulation. Both Klotho and betaKlotho consist of two internal repeats similar to family 1 glycosidases. BetaKlotho contains two glycosyl hydrolase 1 regions, however since these regions lack essential glutamic acid residues at specific and crucial locations, the domains appear to be inactive. |
| Immunogen | KLH conjugated synthetic peptide: human KLB |
| Antigen Species | Human |
| Gene Name | KLB |
| Gene ID | |
| Protein Name | beta-klotho |
| Uniprot ID | |
| Biology Area | Cholesterol Metabolism,Other factors,Energy Metabolism,Cholesterol Metabolism,Cancer,FGF,Energy Metabolism,Lipid metabolism |
| Function | Contributes to the transcriptional repression of cholesterol 7-alpha-hydroxylase (CYP7A1), the rate-limiting enzyme in bile acid synthesis. Probably inactive as a glycosidase. Increases the ability of FGFR1 and FGFR4 to bind FGF21. |
| Molecular Weight | Theoretical: 125 kDa. |
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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