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Anti-Beta Klotho Polyclonal Antibody
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Catalog No. TMAB-00211
Alias Klotho beta-like protein, KLB, BKL, Beta-klotho, BetaKlotho
Anti-Beta Klotho Polyclonal Antibody is a Rabbit antibody targeting Beta Klotho. Anti-Beta Klotho Polyclonal Antibody can be used in WB,IHC-P,IHC-Fr,ICC/IF,IF,ELISA.
Anti-Beta Klotho Polyclonal Antibody
Anti-Beta Klotho Polyclonal Antibody
😃Good
Catalog No. TMAB-00211Alias Klotho beta-like protein, KLB, BKL, Beta-klotho, BetaKlotho
Anti-Beta Klotho Polyclonal Antibody is a Rabbit antibody targeting Beta Klotho. Anti-Beta Klotho Polyclonal Antibody can be used in WB,IHC-P,IHC-Fr,ICC/IF,IF,ELISA.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 50 μL | $220 | 7-10 days | |
| 100 μL | $373 | 7-10 days | |
| 200 μL | $528 | 7-10 days |
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-Beta Klotho Polyclonal Antibody is a Rabbit antibody targeting Beta Klotho. Anti-Beta Klotho Polyclonal Antibody can be used in WB,IHC-P,IHC-Fr,ICC/IF,IF,ELISA. |
| Alias | Klotho beta-like protein, KLB, BKL, Beta-klotho, BetaKlotho |
| Ig Type | IgG |
| Reactivity | (predicted:Human,Mouse,Rat,Sheep) |
| Application | |
| Recommended Dose | WB: 1:500-2000; IHC-P: 1:100-500; IHC-Fr: 1:100-500; ICC/IF: 1:100-500; IF: 1:100-500; ELISA: 1:5000-10000 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Cell membrane. |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Research Background | BetaKlotho is a 1044 amino acid single-pass type III membrane protein that plays a key role in bile acid and cholesterol metabolism by suppressing transcription of CYP7A1 (cholesterol 7-alpha-hydroxylase), the rate-limiting enzyme in bile acid synthesis. Homozygous negative betaKlotho mice showed dramatically elevated bile acid synthesis and secretion, as well as a strong upregulation of CYP7A1 and CYP8B1 and resistance to gallstone formation. FGF19 and FGF21 require direct interaction with betaKlotho for activation, intracellular signaling and gene expression modulation. Both Klotho and betaKlotho consist of two internal repeats similar to family 1 glycosidases. BetaKlotho contains two glycosyl hydrolase 1 regions, however since these regions lack essential glutamic acid residues at specific and crucial locations, the domains appear to be inactive. |
| Immunogen | KLH conjugated synthetic peptide: human KLB |
| Antigen Species | Human |
| Gene ID | |
| Uniprot ID | |
| Biology Area | Cholesterol Metabolism,Other factors,Energy Metabolism,Cholesterol Metabolism,Cancer,FGF,Energy Metabolism,Lipid metabolism |
| Molecular Weight | Theoretical: 125 kDa. |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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