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Pancreatic Polypeptide, rat acetate
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Catalog No. TP1044L
Pancreatic Polypeptide, rat acetate is an agonist of NPY receptor, with high affinity at NPYR4.
Pancreatic Polypeptide, rat acetate
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Purity: 97.53%
Catalog No. TP1044L
Pancreatic Polypeptide, rat acetate is an agonist of NPY receptor, with high affinity at NPYR4.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $238 | - | In Stock | |
| 5 mg | $567 | In Stock | In Stock | |
| 10 mg | $768 | In Stock | In Stock | |
| 25 mg | $1,120 | - | In Stock | |
| 50 mg | $1,530 | - | In Stock | |
| 100 mg | $2,070 | - | In Stock | |
| 200 mg | $2,800 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:97.53%
Appearance:Solid
Color:White
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Pancreatic Polypeptide, rat acetate is an agonist of NPY receptor, with high affinity at NPYR4. |
| Targets&IC50 | NPYY5 receptor (HEK293 cells):0.24 nM, NPYY1 receptor (BHK-21 cells):530 nM, NPYY2 receptor (BHK-21 cells):> 500 nM, NPYY4 receptor (BHK-21 cells):51 nM |
| In vitro | Pancreatic Polypeptide, rat acetate is an agonist of NPY receptor, with high affinity at NPYR4. Pancreatic Polypeptide, rat acetate (1 μM) does not alter proliferation in BRIN BD11 or 1.1B4 beta-cells, but reverses the decreased cell viability in BRIN BD11 cells induced by streptozotocin. Pancreatic Polypeptide, rat acetate (0.1 nM-1 μM) shows no effect on insulin secretion from isolated mouse islets, and does not affect the membrane potential and (Ca2+)i levels in BRIN BD11 cells at 1 μM[1]. |
| In vivo | Pancreatic Polypeptide, rat acetate (25 nmol/kg bw, i.p.) reduces glucose-stimulated insulin concentrations but shows no effect on acute feeding behaviour in overnight fasted mice[1]. |
| Smiles | [H]N[C@H](C(N1CCC[C@H]1C(N[C@@H](CC(C)C)C(N[C@@H](CCC(O)=O)C(N2CCC[C@H]2C(N[C@H](C(N[C@H](C(N3CCC[C@H]3C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@]([C@@H](C)O)([H])C(N[C@H](C(N[C@@H](CCC(O)=O)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(N[C@@H](CCC(N)=O)C(N[C@H](C(N[C@@H](CCC(O)=O)C(N[C@]([C@@H](C)O)([H])C(N[C@@H](CCC(N)=O)C(N[C@@H](CC(C)C)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(N[C@]([C@H](CC)C)([H])C(N[C@@H](CC(N)=O)C(N[C@]([C@@H](C)O)([H])C(N[C@@H](CC(C)C)C(N[C@]([C@@H](C)O)([H])C(N[C@@H](CCCNC(N)=N)C(N4CCC[C@H]4C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(O)=O)CC5=CC=C(O)C=C5)=O)=O)=O)=O)=O)=O)=O)=O)=O)CC6=CC=C(O)C=C6)=O)=O)=O)=O)=O)=O)=O)CC7=CC=C(O)C=C7)=O)=O)C)=O)=O)=O)=O)CC8=CN=CN8)=O)=O)C)=O)CC9=CC=C(O)C=C9)=O)CC(O)=O)=O)=O)=O)CC%10=CC=C(O)C=C%10)=O)CCSC)=O)=O)=O)=O)=O)C |
| Sequence | Ala-Pro-Leu-Glu-Pro-Met-Tyr-Pro-Gly-Asp-Tyr-Ala-Thr-His-Glu-Gln-Arg-Ala-Gln-Tyr-Glu-Thr-Gln-Leu-Arg-Arg-Tyr-Ile-Asn-Thr-Leu-Thr-Arg-Pro-Arg-Tyr-NH2 |
| Sequence Short | APLEPMYPGDYATHEQRAQYETQLRRYINTLTRPRY |
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO: 252.5 mg/mL, Sonication is recommended.  |
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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