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Pancreatic Polypeptide, rat acetate

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Catalog No. TP1044L Copy Product Info
Purity: 97.53%
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Pancreatic Polypeptide, rat acetate is a natural product and an NPY receptor agonist with high affinity for NPYR4 and receptor selectivity, commonly used in experimental models studying energy balance, feeding behavior, and related metabolic diseases.
Pancreatic Polypeptide, rat acetate
Other Forms of Pancreatic Polypeptide, rat acetate:
Pack SizePriceUSA StockGlobal StockQuantity
1 mg$238In StockIn Stock
5 mg$567In StockIn Stock
10 mg$768In StockIn Stock
25 mg$1,120-In Stock
50 mg$1,530-In Stock
100 mg$2,070-In Stock
200 mg$2,800-In Stock
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Batch Information

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Purity:97.53%
Appearance:Solid
Color:White
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COA HPLC MS

Product Introduction

Bioactivity
Description
Pancreatic Polypeptide, rat acetate is a natural product and an NPY receptor agonist with high affinity for NPYR4 and receptor selectivity, commonly used in experimental models studying energy balance, feeding behavior, and related metabolic diseases.
Targets & IC50
NPYY5 receptor (HEK293 cells):0.24 nM, NPYY1 receptor (BHK-21 cells):530 nM, NPYY4 receptor (BHK-21 cells):51 nM, NPYY2 receptor (BHK-21 cells):> 500 nM
In vitro
Methods: In BRIN BD11 or 1.1B4 β cells, Pancreatic Polypeptide, rat acetate (1 μM) was used to assess cell proliferation; in streptozotocin-induced BRIN BD11 cells, Pancreatic Polypeptide, rat acetate (1 μM) was used to assess cell viability; in isolated mouse islets, Pancreatic Polypeptide, rat acetate (0.1 nM–1 μM) was used to assess insulin secretion; in BRIN BD11 cells, Pancreatic Polypeptide, rat acetate (1 μM) was used to assess membrane potential and intracellular calcium levels.
Results: Pancreatic Polypeptide, rat acetate did not alter proliferation in normal β cells but reversed streptozotocin-induced decreases in cell viability; had no effect on insulin secretion from isolated mouse islets; and did not affect membrane potential or intracellular calcium levels in BRIN BD11 cells.[1]
In vivo
Methods: Pancreatic polypeptide (25 nmol/kg bw, intraperitoneal injection) was administered to overnight-fasted mice to assess glucose-stimulated insulin concentrations and acute feeding behavior.
Results: Pancreatic polypeptide reduced glucose-stimulated insulin concentrations but had no effect on acute feeding behavior. [1]
Chemical Properties
Smiles[H]N[C@H](C(N1CCC[C@H]1C(N[C@@H](CC(C)C)C(N[C@@H](CCC(O)=O)C(N2CCC[C@H]2C(N[C@H](C(N[C@H](C(N3CCC[C@H]3C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@]([C@@H](C)O)([H])C(N[C@H](C(N[C@@H](CCC(O)=O)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(N[C@@H](CCC(N)=O)C(N[C@H](C(N[C@@H](CCC(O)=O)C(N[C@]([C@@H](C)O)([H])C(N[C@@H](CCC(N)=O)C(N[C@@H](CC(C)C)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(N[C@]([C@H](CC)C)([H])C(N[C@@H](CC(N)=O)C(N[C@]([C@@H](C)O)([H])C(N[C@@H](CC(C)C)C(N[C@]([C@@H](C)O)([H])C(N[C@@H](CCCNC(N)=N)C(N4CCC[C@H]4C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(O)=O)CC5=CC=C(O)C=C5)=O)=O)=O)=O)=O)=O)=O)=O)=O)CC6=CC=C(O)C=C6)=O)=O)=O)=O)=O)=O)=O)CC7=CC=C(O)C=C7)=O)=O)C)=O)=O)=O)=O)CC8=CN=CN8)=O)=O)C)=O)CC9=CC=C(O)C=C9)=O)CC(O)=O)=O)=O)=O)CC%10=CC=C(O)C=C%10)=O)CCSC)=O)=O)=O)=O)=O)C
SequenceAla-Pro-Leu-Glu-Pro-Met-Tyr-Pro-Gly-Asp-Tyr-Ala-Thr-His-Glu-Gln-Arg-Ala-Gln-Tyr-Glu-Thr-Gln-Leu-Arg-Arg-Tyr-Ile-Asn-Thr-Leu-Thr-Arg-Pro-Arg-Tyr-NH₂
Sequence ShortAPLEPMYPGDYATHEQRAQYETQLRRYINTLTRPRY
Storage & Solubility Information
StorageKeep away from moisture Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 252.5 mg/mL, Sonication is recommended.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 µL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
mg/kg
g
µL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Pancreatic Polypeptide, rat acetateNeuropeptideYReceptorNeuropeptide Y Receptorneuropeptide Y (NPY) receptor
Related Tags: Pancreatic Polypeptide, rat acetate chemical structure | Pancreatic Polypeptide, rat acetate in vivo | Pancreatic Polypeptide, rat acetate in vitro
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